The use of live biocatalysts for pesticide detoxification.

During the past decade, numerous microorganisms capable of degrading pesticides have been isolated, and detoxification processes based on these live biocatalysts have been developed. Recently, novel detoxification strategies using genetically engineered microorganisms with extended degradative capabilities have been investigated and, in some cases, shown to be more effective. One promising approach for the detoxification of organophosphate pesticides uses genetically engineered Escherichia coli with surface-expressed organophosphorus hydrolase. Continuous efforts in this direction are required, in conjunction with a search for microorganisms capable of degrading pesticides rapidly, to establish efficient and cost-effective large-scale processes for pesticide detoxification.