Literature DB >> 9487522

The delivery of angiogenic factors to the heart by microsphere therapy.

M Arras1, H Mollnau, R Strasser, R Wenz, W D Ito, J Schaper, W Schaper.   

Abstract

Microspheres offer the possibility of local noninvasive delivery of drugs over an extended period of time. We adsorbed fibroblast growth factor (FGF) to microspheres of precapillary size that were injected via a coronary catheter. We showed that FGF was released from these microspheres and taken up by endothelial cells, which proliferated following translocation of FGF to the nucleus. This method for application of growth factors allows the precise delivery of angiogenic substances to any selected part of the heart or other organs without causing inflammation or ischemia.

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Year:  1998        PMID： 9487522     DOI： 10.1038/nbt0298-159

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  10 in total

1.  Clinical improvement and enhanced collateral vessel growth after xenogenic monocyte transplantation.

Authors:  Martin Wagner; Adrian Mahlmann; Elisabeth Deindl; Werner Zuschratter; Monika Riek-Burchardt; Sawa Kostin; Blerim Luani; Claudia Baer; Akram Youssef; Joerg Herold
Journal:  Am J Transl Res       Date:  2019-07-15       Impact factor: 4.060

Review 2.  Cardiovascular gene delivery: The good road is awaiting.

Authors:  L P Brewster; E M Brey; H P Greisler
Journal:  Adv Drug Deliv Rev       Date:  2006-07-07       Impact factor: 15.470

3.  Neovascularization of ischemic myocardium by newly isolated tannins prevents cardiomyocyte apoptosis and improves cardiac function.

Authors:  Xuemei Gu; Lei Cheng; Winghong L Chueng; Xinsheng Yao; Hongwei Liu; Guoqing Qi; Ming Li
Journal:  Mol Med       Date:  2006 Nov-Dec       Impact factor: 6.354

4.  Del-1 gene transfer induces cerebral angiogenesis in mice.

Authors:  Yongfeng Fan; Wei Zhu; Michael Yang; Yiqian Zhu; Fanxia Shen; Qi Hao; William L Young; Guo-Yuan Yang; Yongmei Chen
Journal:  Brain Res       Date:  2008-05-10       Impact factor: 3.252

5.  Cell-responsive hydrogel for encapsulation of vascular cells.

Authors:  Thomas P Kraehenbuehl; Lino S Ferreira; Prisca Zammaretti; Jeffrey A Hubbell; Robert Langer
Journal:  Biomaterials       Date:  2009-06-04       Impact factor: 12.479

6.  Testing clinical therapeutic angiogenesis using basic fibroblast growth factor (FGF-2).

Authors:  Ronnier J Aviles; Brian H Annex; Robert J Lederman
Journal:  Br J Pharmacol       Date:  2003-10       Impact factor: 8.739

7.  MMP-sensitive PEG hydrogel modified with RGD promotes bFGF, VEGF and EPC-mediated angiogenesis.

Authors:  Liu Ouyang; Yang Dan; Zengwu Shao; Shuhua Yang; Cao Yang; Guohui Liu; Deyu Duan
Journal:  Exp Ther Med       Date:  2019-08-13       Impact factor: 2.447

Review 8.  Collateral circulation: past and present.

Authors:  Wolfgang Schaper
Journal:  Basic Res Cardiol       Date:  2008-12-20       Impact factor: 17.165

9.  Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation.

Authors:  T Korff; H G Augustin
Journal:  J Cell Biol       Date:  1998-11-30       Impact factor: 10.539

10.  Tetanus toxoid-pulsed monocyte vaccination for augmentation of collateral vessel growth.

Authors:  Joerg Herold; Alexander Francke; Soenke Weinert; Alexander Schmeisser; Katrin Hebel; Burkhart Schraven; Friedich-Wilhelm Roehl; Ruth H Strasser; Ruediger C Braun-Dullaeus
Journal:  J Am Heart Assoc       Date:  2014-04-14       Impact factor: 5.501
  10 in total

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