Literature DB >> 948751

Cholesterogenesis: derepression in extrahepatic tissues with 4-aminopyrazolo (3,4-d) pyrimidine.

J M Andersen, J M Dietschy.   

Abstract

Administration of 4-aminopyrazolo [3,4-d] pyrimidine decreased serum cholesterol levels in the rat to less than 5 milligrams per deciliter. Coincident with this change, there was a 2.1 - to 16.0-fold increase in the rate of sterol synthesis in seven extrahepatic tissues. This suggests that cholesterol carried in serum lipoproteins plays a major role in regulating sterol synthesis in many extrahepatic tissues.

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Year:  1976        PMID： 948751     DOI： 10.1126/science.948751

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.

Authors:  S Balasubramaniam; J L Goldstein; M S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

2.  Low and high density lipoproteins and chylomicrons as regulators of rate of cholesterol synthesis in rat liver in vivo.

Authors:  J M Andersen; S D Turley; J M Dietschy
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

3.  4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.

Authors:  M Brigotti; D Carnicelli; P Accorsi; S Rizzi; L Montanaro; S Sperti
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

4.  Immunohistochemical localization of low density lipoprotein receptors in adrenal gland, liver, and intestine.

Authors:  L G Fong; E Bonney; J C Kosek; A D Cooper
Journal:  J Clin Invest       Date:  1989-09       Impact factor: 14.808

Review 5.  Regulation of cholesterol metabolism in man and in other species.

Authors:  J M Dietschy
Journal:  Klin Wochenschr       Date:  1984-04-16

6.  Metabolic studies in an unusual case of asymptomatic familial hypobetalipoproteinemia with hypolphalipoproteinemia and fasting chylomicronemia.

Authors:  D Steinberg; S M Grundy; H Y Mok; J D Turner; D B Weinstein; W V Brown; J J Albers
Journal:  J Clin Invest       Date:  1979-07       Impact factor: 14.808

7.  Regulation of acylcoenzyme A. Cholesterol acyltransferase and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by lipoproteins in the intestine of parabiont rats.

Authors:  B H Purdy; F J Field
Journal:  J Clin Invest       Date:  1984-08       Impact factor: 14.808

Review 8.  The metabolic basis of familial hypercholesterolemia.

Authors:  N B Myant
Journal:  Klin Wochenschr       Date:  1983-04-15

9.  The preparation and purification of isolated rat corpus-luteum cells and their use in studying the relationship between cholesterol biosynthesis and the lutropin-stimulated formation of progesterone.

Authors:  B C McNamara; C E Cranna; R Booth; D A Stansfield
Journal:  Biochem J       Date:  1980-11-15       Impact factor: 3.857

10.  Evidence for the operation of the extrahepatic lipoprotein receptor system in vivo in rats. Effect of dietary cholesterol and orotic acid, alone or in combination, on the rate of synthesis of cholesterol and fatty acid in various tissues, measured by using 3H2O.

Authors:  R Fears; A M Umpleby
Journal:  Biochem J       Date:  1979-09-15       Impact factor: 3.857
  10 in total

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