Literature DB >> 9486476

Synergy between TGF-beta 3 and NT-3 to promote the survival of spiral ganglia neurones in vitro.

P L Marzella1, G M Clark, R K Shepherd, P F Bartlett, T J Kilpatrick.   

Abstract

Transforming growth factor-betas (TGF-betas) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF-beta3 and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings from this study suggest that TGF-beta3 supports neuronal survival in a concentration-dependent manner. Moreover TGF-beta3 and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion.

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Year:  1998        PMID： 9486476     DOI： 10.1016/s0304-3940(97)00928-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

1.  Exogenous BDNF rescues rat spiral ganglion neurons in vivo.

Authors:  Sarah L McGuinness; Robert K Shepherd
Journal:  Otol Neurotol       Date:  2005-09       Impact factor: 2.311

Review 2.  Clinical application of neurotrophic factors: the potential for primary auditory neuron protection.

Authors:  Lisa N Gillespie; Robert K Shepherd
Journal:  Eur J Neurosci       Date:  2005-11       Impact factor: 3.386

3.  Neurotrophins differentially stimulate the growth of cochlear neurites on collagen surfaces and in gels.

Authors:  Joanna Xie; Kwang Pak; Amaretta Evans; Andy Kamgar-Parsi; Stephen Fausti; Lina Mullen; Allen Frederic Ryan
Journal:  Neural Regen Res       Date:  2013       Impact factor: 5.135

4.  Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants.

Authors:  Claudia Frick; Stefan Fink; Dominik Schmidbauer; Francis Rousset; Holger Eickhoff; Anke Tropitzsch; Benedikt Kramer; Pascal Senn; Rudolf Glueckert; Helge Rask-Andersen; Karl-Heinz Wiesmüller; Hubert Löwenheim; Marcus Müller
Journal:  Brain Sci       Date:  2020-08-21

5.  WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro.

Authors:  Francis Rousset; Giulia Schilardi; Stéphanie Sgroi; German Nacher-Soler; Rebecca Sipione; Sonja Kleinlogel; Pascal Senn
Journal:  Cells       Date:  2022-08-05       Impact factor: 7.666
  5 in total

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