Literature DB >> 9486102

Circulating immune complexes from HIV-1+ patients induces apoptosis on normal lymphocytes.

E Aceituno1, S Castañón, C Jiménez, D Subirá, M De Górgolas, M Fernández-Guerrero, F Ortíz, R García.   

Abstract

Isolated immune complexes from sera of 49 out of 67 human immunodeficiency virus-1-positive (HIV-1+) patients (CIC-HIV+), composed of anti-HIV-HIV-Ag, could induce apoptosis on normal phytohaemagglutinin (PHA)-activated lymphocytes. DNA degradation was detected by propidium iodide staining. This activity is directed against CD4+ lymphocytes as demonstrated by double binding of CIC-HIV+ and anti-CD4 on apoptosis cells. Expression of Fas antigen is prior to apoptotic phenomena. CIC-HIV+ apoptosis inducers belong mainly to asymptomatic HIV-infected patients, indicating that immune complexes from these patients can destroy CD4+ lymphocytes.

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Year:  1997        PMID： 9486102      PMCID： PMC1363790          DOI： 10.1046/j.1365-2567.1997.00361.x

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  16 in total

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2.  Gallid Herpesvirus 1 Initiates Apoptosis in Uninfected Cells through Paracrine Repression of p53.

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