Lateral preference in post-traumatic stress disorder.

BACKGROUND: We assessed lateral preference in 80 male patients with combat-related post-traumatic stress disorder (PTSD) and in 100 healthy age-matched male controls.
METHODS: Hand, foot, eye and ear preferences were examined, using the Edinburgh Handedness Inventory-Modified and the Coren Inventory of Lateral Preference.
RESULTS: Mixed lateral preference was noted in significantly more PTSD patients than controls (65 v. 43%, P < 0.005).
CONCLUSIONS: These results indicate a possible hemispheric imbalance (less lateralization) in PTSD patients, with the right hemisphere playing a more active role in perceptual and cognitive processing and in the regulation of biological responses in these patients. This imbalance may be relevant to the pathophysiology of PTSD.