| Literature DB >> 948354 |
D A Taylor, D P Westfall, S De Moraes, W W Fleming.
Abstract
It has previously been suggested that the reserpine-induced nonspecific increase in sensitivity of the guinea-pig heart to the chronotropic effect od drugs occurs as a result of an alteration in the electrophysiological properties of the cell membrane. The results obtained in the present study provide support for this suggestion. The diastolic potential of atrial cells of perfused hearts obtained from guinea pigs treated with rerpine (0.1 mg/kg/day) for 7 days was significantly less than control. This treatment schedule of reserpine results in a significant increase in the sensitivity of perfoused hearts to the chronotropic effects of drugs...Entities:
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Year: 1976 PMID： 948354 DOI： 10.1007/bf00498874
Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000