Literature DB >> 9481820

The role of CpG dinucleotides in DNA vaccines.

A M Krieg1, A K Yi, J Schorr, H L Davis.   

Abstract

DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.

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Year:  1998        PMID： 9481820     DOI： 10.1016/S0966-842X(97)01145-1

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  35 in total

1.  Genome-scale compositional comparisons in eukaryotes.

Authors:  A J Gentles; S Karlin
Journal:  Genome Res       Date:  2001-04       Impact factor: 9.043

2.  Myth, menace or medical blessing? The clinical potential and the problems of genetic vaccines.

Authors:  W W Leitner
Journal:  EMBO Rep       Date:  2001-03       Impact factor: 8.807

3.  Genome signature comparisons among prokaryote, plasmid, and mitochondrial DNA.

Authors:  A Campbell; J Mrázek; S Karlin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

Review 4.  The role of CpG in DNA vaccines.

Authors:  M J McCluskie; R D Weeratna; H L Davis
Journal:  Springer Semin Immunopathol       Date:  2000

5.  Marked enhancement of the antigen-specific immune response by combining plasmid DNA-based immunization with a Schiff base-forming drug.

Authors:  Jehad Charo; Maria Sundbäck; Ken Wasserman; Anne-Marie T Ciupitu; Babak Mirzai; Ruurd van der Zee; Rolf Kiessling
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

Review 6.  Coccidioidomycosis: host response and vaccine development.

Authors:  Rebecca A Cox; D Mitchell Magee
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

7.  Herpes simplex virus type 1 DNA is immunostimulatory in vitro and in vivo.

Authors:  Patric Lundberg; Paula Welander; Xiao Han; Edouard Cantin
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

8.  Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotides.

Authors:  Purushottam Kaushik; Dhirendra K Singh; S Vinoth Kumar; Ashok K Tiwari; Gunjan Shukla; Shanker Dayal; Pallav Chaudhuri
Journal:  Vet Res Commun       Date:  2009-12-16       Impact factor: 2.459

9.  Tweaking Innate Immunity: the Promise of Innate Immunologicals As Anti-infectives.

Authors:  Kenneth L Rosenthal
Journal:  Can J Infect Dis Med Microbiol       Date:  2006-09       Impact factor: 2.471

10.  Dissecting the immune response to moloney murine sarcoma/leukemia virus-induced tumors by means of a DNA vaccination approach.

Authors:  G Milan; A Zambon; M Cavinato; P Zanovello; A Rosato; D Collavo
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103
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