| Literature DB >> 9480863 |
D Thomas1, H Y Kim, R Morgan, M R Hanley.
Abstract
Expression of the double-stranded-RNA-dependent protein kinase (PKR) in Xenopus oocytes attenuated Ca2+ entry-dependent membrane currents activated by depletion of Ca2+ stores, whereas expression of a dominant-negative PKR mutant had the opposite effect. These results appeared to be due to perturbation of releasable Ca2+ stores, and not actions of PKR on protein synthesis. PKR may thus have novel protein substrates and cellular functions in Ca2+ storage and signalling.Entities:
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Year: 1998 PMID: 9480863 PMCID: PMC1219178 DOI: 10.1042/bj3300599
Source DB: PubMed Journal: Biochem J ISSN: 0264-6021 Impact factor: 3.857