Ultrasonic modulation of scattered light in turbid media and a potential novel tomography in biomedicine.

Ultrasonic modulation of scattered laser light was used to image objects buried in tissue-simulating turbid media. The ultrasonic wave focused into the turbid media modulated the laser light passing through the ultrasonic field. The modulated laser light collected by a photomultiplier tube reflected primarily the local mechanical and optical properties in the zone of ultrasonic modulation. A raster scanning over a heterogeneous turbid medium yielded an image of the medium based on the ultrasound-modulated optical signal. The detectability of modulated signal was estimated using diffusion theory. The dependence of the modulated signal on the off-axis distance of the detector from the optic axis and on the amplitude of ultrasound was studied. The mechanisms of ultrasonic modulation of scattered light are discussed. A theory based on the field autocorrelation function is reviewed as well.