Literature DB >> 9477307

Differential expression of type XIV collagen/undulin by human mammary gland intralobular and interlobular fibroblasts.

A J Atherton1, M J Warburton, M J O'Hare, P Monaghan, D Schuppan, B A Gusterson.   

Abstract

Immunolocalisation of type XIV collagen/undulin in the human mammary gland revealed greater deposition in the interlobular stroma than in the intralobular stroma. The interlobular stroma is located between the breast lobules and their associated intralobular stroma. Fibroblasts isolated from the interlobular stroma synthesised 3- to 5-fold more type XIV collagen/undulin than intralobular fibroblasts, but synthesised type I and type IV collagens in similar amounts. The differential expression of type XIV collagen/undulin was maintained with passage in culture. The results suggest a role for type XIV collagen/undulin in stabilising dense collagen fibrils. The maintenance of two types of structurally distinct stromas may be important during developmental processes in the mammary gland.

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Year:  1998        PMID： 9477307     DOI： 10.1007/s004410051020

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  7 in total

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3.  Evidence of two distinct functionally specialized fibroblast lineages in breast stroma.

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4.  Single-Cell Transcriptomics Identifies Heterogeneity of Mouse Mammary Gland Fibroblasts With Distinct Functions, Estrogen Responses, Differentiation Processes, and Crosstalks With Epithelium.

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Journal:  Front Cell Dev Biol       Date:  2022-03-01

5.  Interlobular and intralobular mammary stroma: genotype may not reflect phenotype.

Authors:  J M Fleming; E L Long; E Ginsburg; D Gerscovich; P S Meltzer; B K Vonderhaar
Journal:  BMC Cell Biol       Date:  2008-08-18       Impact factor: 4.241

Review 6.  Of mice and women: a comparative tissue biology perspective of breast stem cells and differentiation.

Authors:  Gabriela Dontu; Tan A Ince
Journal:  J Mammary Gland Biol Neoplasia       Date:  2015-08-19       Impact factor: 2.673

7.  Fibroblasts direct differentiation of human breast epithelial progenitors.

Authors:  Mikkel Morsing; Jiyoung Kim; René Villadsen; Nadine Goldhammer; Abbas Jafari; Moustapha Kassem; Ole William Petersen; Lone Rønnov-Jessen
Journal:  Breast Cancer Res       Date:  2020-09-29       Impact factor: 6.466
  7 in total

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