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Literature DB >> 9477174

Platelet activating factor antagonist activity of ginsenosides.

K Y Jung¹, D S Kim, S R Oh, I S Lee, J J Lee, J D Park, S I Kim, H K Lee.

Abstract

Ginseng saponins and their degradation products have been screened for antagonist activity towards [3H]PAF (platelet activating factor) in washed rabbit platelet receptor binding studies. 20(S)- and delta20-ginsenosides Rg3, protopanaxadiol-type saponins, were found to be relatively potent PAF antagonists (IC50 = 4.9 x 10(-5) M and 9.2 x 10(-5) M, respectively).

Entities: Chemical Species

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Year: 1998 PMID： 9477174 DOI： 10.1248/bpb.21.79

Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233

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Cited

10 in total

1. Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation.

Authors: M Endale; W M Lee; S M Kamruzzaman; S D Kim; J Y Park; M H Park; T Y Park; H J Park; J Y Cho; M H Rhee
Journal: Br J Pharmacol Date: 2012-09 Impact factor: 8.739

Review 2. Herb-drug interactions: a literature review.

Authors: Zeping Hu; Xiaoxia Yang; Paul Chi Lui Ho; Sui Yung Chan; Paul Wan Sia Heng; Eli Chan; Wei Duan; Hwee Ling Koh; Shufeng Zhou
Journal: Drugs Date: 2005 Impact factor: 9.546

Review 3. Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine.

Authors: Lee Jia; Yuqing Zhao; Xing-Jie Liang
Journal: Curr Med Chem Date: 2009 Impact factor: 4.530

4. The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation.

Authors: Bo Ra Jeon; Su Jung Kim; Seung Bok Hong; Hwa-Jin Park; Jae Youl Cho; Man Hee Rhee
Journal: J Ginseng Res Date: 2015-02-23 Impact factor: 6.060

5. The inhibitory activity of ginsenoside Rp4 in adenosine diphosphate-induced platelet aggregation.

Authors: Young-Min Son; Da-Hye Jeong; Hwa-Jin Park; Man-Hee Rhee
Journal: J Ginseng Res Date: 2016-02-15 Impact factor: 6.060

6. Platelet-activating factor receptor antagonists of natural origin for acute ischemic stroke: a systematic review of current evidence.

Authors: Tingting Li; Xuebin Zhang; Ping Jiang; Dandan Zhang; Luda Feng; Xinxing Lai; Mingzhen Qin; Yufei Wei; Chi Zhang; Ying Gao
Journal: Front Pharmacol Date: 2022-08-31 Impact factor: 5.988

Platelet activating factor antagonist activity of ginsenosides.

1. Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation.

Review 2. Herb-drug interactions: a literature review.

Review 3. Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine.

4. The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation.

5. The inhibitory activity of ginsenoside Rp4 in adenosine diphosphate-induced platelet aggregation.

6. Platelet-activating factor receptor antagonists of natural origin for acute ischemic stroke: a systematic review of current evidence.

7. Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats.

8. Protective Effect of Heat-processed Ginseng (Sun Ginseng) in the Adenine-induced Renal Failure Rats.

9. Changes in the contents of prosapogenin in Red ginseng (Panax ginseng) depending on the extracting conditions.

10. Modification of ginsenoside composition in red ginseng (Panax ginseng) by ultrasonication.