M P Castro1. 1. Glens Falls Cancer Center, New York 12801, USA.
Abstract
BACKGROUND: Advanced carcinoma of the gallbladder typically is unresponsive to chemotherapy, and patients with progressive metastatic disease have a short survival. METHODS: A patient with advanced metastatic carcinoma of the gallbladder causing peritoneal carcinomatosis and hepatic metastases is reported. This patient achieved a dramatic remission with gemcitabine after failing two other chemotherapeutic regimens. RESULTS: Response included reversal of complete small bowel obstruction with resumption of the ability to eat and the disappearance of liver metastases. CONCLUSIONS: Gemcitabine appears to be worthy of organized clinical trials in patients with this notoriously chemotherapy-resistant malignancy.
BACKGROUND: Advanced carcinoma of the gallbladder typically is unresponsive to chemotherapy, and patients with progressive metastatic disease have a short survival. METHODS: A patient with advanced metastatic carcinoma of the gallbladder causing peritoneal carcinomatosis and hepatic metastases is reported. This patient achieved a dramatic remission with gemcitabine after failing two other chemotherapeutic regimens. RESULTS: Response included reversal of complete small bowel obstruction with resumption of the ability to eat and the disappearance of liver metastases. CONCLUSIONS:Gemcitabine appears to be worthy of organized clinical trials in patients with this notoriously chemotherapy-resistant malignancy.
Authors: Syma Iqbal; Cathryn Rankin; Heinz-Josef Lenz; Philip J Gold; Syed A Ahmad; Anthony B El-Khoueiry; Michael J Messino; Randall F Holcombe; Charles D Blanke Journal: Cancer Chemother Pharmacol Date: 2011-05-10 Impact factor: 3.333
Authors: Brian A Costello; Mitesh J Borad; Yingwei Qi; George P Kim; Donald W Northfelt; Charles Erlichman; Steven R Alberts Journal: Invest New Drugs Date: 2014-04-18 Impact factor: 3.850
Authors: Steven R Alberts; Jonathan R Sande; Nathan R Foster; Fernando J Quevedo; Robert R McWilliams; John W Kugler; Tom R Fitch; Anthony J Jaslowski Journal: J Gastrointest Cancer Date: 2008-11-21
Authors: Adriana Romiti; Chiara D'Antonio; Angelo Zullo; Ida Sarcina; Roberta Di Rocco; Viola Barucca; Valeria Durante; Paolo Marchetti Journal: J Gastrointest Cancer Date: 2012-09