Vaginal metastases from renal cell carcinoma: report of four cases and review of the literature.

Between 1987 and 1997, four patients presented with gynecologic symptoms that on evaluation revealed vaginal metastases from renal cell carcinoma. Two patients had isolated metastases and were treated with nephrectomy, local excision of the vaginal lesion and post-operative radiotherapy. Both are alive without evidence of disease at 24 and 30 months, respectively. The other two patients had widespread disease and died within a year of diagnosis. Seventy-one cases of vaginal metastases from renal cell carcinoma have been reported in the literature.