PURPOSE: Because few studies have described the impact of unilateral testicular trauma on fertility parameters, we review the experience at the Ben Taub General Hospital during a 16-year period. Semen and endocrine profiles were analyzed to evaluate the influence on the outcomes of orchiectomy versus testicular salvage. MATERIALS AND METHODS: From 1979 to 1995, 67 patients were identified who sustained unilateral testicular trauma. Of these patients 12 were located and 10 agreed to be evaluated. Injuries included gunshot wounds, stab wounds and blunt trauma, and treatment consisted of unilateral orchiectomy or testicular repair. The study protocol comprised a history and physical examination, routine semen analysis, determination of semen and serum antisperm antibody titers (Immunobead* assay) and a modified gonadotropin stimulation test. Results were compared with a group of semen donors with proved fertility. RESULTS: In the 7 patients who underwent unilateral orchiectomy mean sperm density was normal but significantly decreased compared with that of the fertile controls (81.6 versus 132.6 x 10(6)/ml., p = 0.04). Sperm motility was not significantly affected. Baseline follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and post-stimulation LH were significantly increased in this group compared with controls (p < 0.01). In the group that underwent testicular repair sperm density, motility, and baseline and post-stimulation FSH and LH levels were not significantly different from controls. In all patients in both groups testosterone levels and contralateral testicular size were normal. Only 1 patient in the repair group had an elevated serum and semen antisperm titer. CONCLUSIONS: While the testicular salvage group had no significant seminal or endocrine abnormality, the orchiectomy group had a significant decrease in sperm density and elevation of baseline FSH and LH. These preliminary data suggest that testicular salvage is more protective of overall testicular function than orchiectomy.
PURPOSE: Because few studies have described the impact of unilateral testicular trauma on fertility parameters, we review the experience at the Ben Taub General Hospital during a 16-year period. Semen and endocrine profiles were analyzed to evaluate the influence on the outcomes of orchiectomy versus testicular salvage. MATERIALS AND METHODS: From 1979 to 1995, 67 patients were identified who sustained unilateral testicular trauma. Of these patients 12 were located and 10 agreed to be evaluated. Injuries included gunshot wounds, stab wounds and blunt trauma, and treatment consisted of unilateral orchiectomy or testicular repair. The study protocol comprised a history and physical examination, routine semen analysis, determination of semen and serum antisperm antibody titers (Immunobead* assay) and a modified gonadotropin stimulation test. Results were compared with a group of semen donors with proved fertility. RESULTS: In the 7 patients who underwent unilateral orchiectomy mean sperm density was normal but significantly decreased compared with that of the fertile controls (81.6 versus 132.6 x 10(6)/ml., p = 0.04). Sperm motility was not significantly affected. Baseline follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and post-stimulation LH were significantly increased in this group compared with controls (p < 0.01). In the group that underwent testicular repair sperm density, motility, and baseline and post-stimulation FSH and LH levels were not significantly different from controls. In all patients in both groups testosterone levels and contralateral testicular size were normal. Only 1 patient in the repair group had an elevated serum and semen antisperm titer. CONCLUSIONS: While the testicular salvage group had no significant seminal or endocrine abnormality, the orchiectomy group had a significant decrease in sperm density and elevation of baseline FSH and LH. These preliminary data suggest that testicular salvage is more protective of overall testicular function than orchiectomy.
Authors: Lisa B Kenney; Laurie E Cohen; Margarett Shnorhavorian; Monika L Metzger; Barbara Lockart; Nobuko Hijiya; Eileen Duffey-Lind; Louis Constine; Daniel Green; Lillian Meacham Journal: J Clin Oncol Date: 2012-05-29 Impact factor: 44.544
Authors: Sajal Gupta; Rakesh Sharma; Ashok Agarwal; Florence Boitrelle; Renata Finelli; Ala'a Farkouh; Ramadan Saleh; Taha Abo-Almagd Abdel-Meguid; Murat Gül; Birute Zilaitiene; Edmund Ko; Amarnath Rambhatla; Armand Zini; Kristian Leisegang; Shinnosuke Kuroda; Ralf Henkel; Rossella Cannarella; Ayad Palani; Chak-Lam Cho; Christopher C K Ho; Daniel Suslik Zylbersztejn; Edoardo Pescatori; Eric Chung; Fotios Dimitriadis; Germar-Michael Pinggera; Gian Maria Busetto; Giancarlo Balercia; Gianmaria Salvio; Giovanni M Colpi; Gökhan Çeker; Hisanori Taniguchi; Hussein Kandil; Hyun Jun Park; Israel Maldonado Rosas; Jean de la Rosette; Joao Paulo Greco Cardoso; Jonathan Ramsay; Juan Alvarez; Juan Manuel Corral Molina; Kareim Khalafalla; Kasonde Bowa; Kelton Tremellen; Evangelini Evgeni; Lucia Rocco; Marcelo Gabriel Rodriguez Peña; Marjan Sabbaghian; Marlon Martinez; Mohamed Arafa; Mohamed S Al-Marhoon; Nicholas Tadros; Nicolas Garrido; Osvaldo Rajmil; Pallav Sengupta; Paraskevi Vogiatzi; Parviz Kavoussi; Ponco Birowo; Raghavender Kosgi; Saleem Bani-Hani; Sava Micic; Sijo Parekattil; Sunil Jindal; Tan V Le; Taymour Mostafa; Tuncay Toprak; Yoshiharu Morimoto; Vineet Malhotra; Azin Aghamajidi; Damayanthi Durairajanayagam; Rupin Shah Journal: World J Mens Health Date: 2022-01-01 Impact factor: 6.494