| Literature DB >> 9473725 |
S Shimohama1, D L Greenwald, D H Shafron, A Akaika, T Maeda, S Kaneko, J Kimura, C E Simpkins, A L Day, E M Meyer.
Abstract
The alpha7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha7 receptors appear neuroprotective in non-apoptotic model.Entities:
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Year: 1998 PMID： 9473725 DOI： 10.1016/s0006-8993(97)00194-7
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252