Literature DB >> 9472091

Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.

T Otsuki1, N Nakazawa, M Taniwaki, O Yamada, H Sakaguchi, H Wada, Y Yawata, A Ueki.   

Abstract

A new human myeloma cell line, KMS-18, was established from a 58-year-old male with multiple myeloma associated with hyperammonemia. The original leukemic cells and established KMS-18 cells possessed several of the same chromosomal abnormalities, including add(1)(q32), add(10) (q24) and add(17)(p11). In addition, the KMS-18 cells showed novel t(4;14)(p16.3;q32.3) masked translocation which was determined by the FISH method. Moreover, we compared the ammonia production in culture medium of the KMS-18 cell line with that of non-myeloma hematological malignant cell lines and a hepatocellular carcinoma cell line. KMS-18 produced higher levels of ammonia in medium than the other cell lines examined. This new cell line may prove helpful in analyzing the role and biological mechanisms of the t(4;14)(p16.3;q32.3) translocation in myeloma and also in investigating hyperammonemia in cases with myeloma.

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Year:  1998        PMID： 9472091     DOI： 10.3892/ijo.12.3.545

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  9 in total

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Review 2.  Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.

Authors:  Edwin Li; Kalina Hristova
Journal:  Biochemistry       Date:  2006-05-23       Impact factor: 3.162

3.  Forster resonance energy transfer measurements of transmembrane helix dimerization energetics.

Authors:  Mikhail Merzlyakov; Kalina Hristova
Journal:  Methods Enzymol       Date:  2008       Impact factor: 1.600

4.  Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients.

Authors:  Jonathan J Keats; Christopher A Maxwell; Brian J Taylor; Michael J Hendzel; Marta Chesi; P Leif Bergsagel; Loree M Larratt; Michael J Mant; Tony Reiman; Andrew R Belch; Linda M Pilarski
Journal:  Blood       Date:  2005-01-27       Impact factor: 22.113

5.  Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma.

Authors:  P Leif Bergsagel; W Michael Kuehl; Fenghuang Zhan; Jeffrey Sawyer; Bart Barlogie; John Shaughnessy
Journal:  Blood       Date:  2005-03-08       Impact factor: 22.113

6.  Studies of receptor tyrosine kinase transmembrane domain interactions: the EmEx-FRET method.

Authors:  Mikhail Merzlyakov; Lirong Chen; Kalina Hristova
Journal:  J Membr Biol       Date:  2007-06-14       Impact factor: 1.843

7.  The strong dimerization of the transmembrane domain of the fibroblast growth factor receptor (FGFR) is modulated by C-terminal juxtamembrane residues.

Authors:  Weng Chuan Peng; Xin Lin; Jaume Torres
Journal:  Protein Sci       Date:  2009-02       Impact factor: 6.725

8.  Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib.

Authors:  Tamer B Shabaneh; Sondra L Downey; Ayrton L Goddard; Michael Screen; Marcella M Lucas; Alan Eastman; Alexei F Kisselev
Journal:  PLoS One       Date:  2013-02-27       Impact factor: 3.240

9.  Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Authors:  Kar-Tong Tan; Ling-Wen Ding; Qiao-Yang Sun; Zhen-Tang Lao; Wenwen Chien; Xi Ren; Jin-Fen Xiao; Xin Yi Loh; Liang Xu; Michael Lill; Anand Mayakonda; De-Chen Lin; Henry Yang; H Phillip Koeffler
Journal:  BMC Cancer       Date:  2018-10-01       Impact factor: 4.430
  9 in total

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