OBJECTIVE: To evaluate the ratio of peak oxygen consumption to peak heart rate (peak oxygen pulse) as a predictor of long term prognosis in chronic heart failure. PATIENTS AND SETTING: 178 consecutive heart failure patients recruited to the cardiology department of a tertiary referral centre between 1986 and 1993. DESIGN: Bicycle ergometry with measurement of respiratory exchange. Mean (SD) follow up was 32 (25) months. RESULTS: Patients who died had a lower peak oxygen consumption (16.0 (5.5) v 18.0 (5.5) ml/min/kg, p = 0.05), lower indexed peak oxygen consumption (52 (14) v 60 (16)%, p = 0.006) but similar peak oxygen pulse (8.4 (2.6) v 8.4 (3.0) ml/beat, NS). The following variables were associated with a good long term prognosis: New York Heart Association class II, non-ischaemic heart failure, peak oxygen consumption > or = 17 ml/min/kg, indexed peak oxygen consumption > 63%. Peak oxygen pulse did not have predictive value. Only indexed peak oxygen consumption remained an independent predictor of survival in multivariate analysis. CONCLUSIONS: Peak oxygen pulse has lower prognostic value than peak oxygen consumption, especially when the latter is indexed to predicted values.
OBJECTIVE: To evaluate the ratio of peak oxygen consumption to peak heart rate (peak oxygen pulse) as a predictor of long term prognosis in chronic heart failure. PATIENTS AND SETTING: 178 consecutive heart failurepatients recruited to the cardiology department of a tertiary referral centre between 1986 and 1993. DESIGN: Bicycle ergometry with measurement of respiratory exchange. Mean (SD) follow up was 32 (25) months. RESULTS:Patients who died had a lower peak oxygen consumption (16.0 (5.5) v 18.0 (5.5) ml/min/kg, p = 0.05), lower indexed peak oxygen consumption (52 (14) v 60 (16)%, p = 0.006) but similar peak oxygen pulse (8.4 (2.6) v 8.4 (3.0) ml/beat, NS). The following variables were associated with a good long term prognosis: New York Heart Association class II, non-ischaemic heart failure, peak oxygen consumption > or = 17 ml/min/kg, indexed peak oxygen consumption > 63%. Peak oxygen pulse did not have predictive value. Only indexed peak oxygen consumption remained an independent predictor of survival in multivariate analysis. CONCLUSIONS: Peak oxygen pulse has lower prognostic value than peak oxygen consumption, especially when the latter is indexed to predicted values.
Authors: M R Bristow; R Ginsburg; V Umans; M Fowler; W Minobe; R Rasmussen; P Zera; R Menlove; P Shah; S Jamieson Journal: Circ Res Date: 1986-09 Impact factor: 17.367
Authors: L W Stevenson; A E Steimle; G Fonarow; M Kermani; D Kermani; M A Hamilton; J D Moriguchi; J Walden; J H Tillisch; D C Drinkwater Journal: J Am Coll Cardiol Date: 1995-01 Impact factor: 24.094
Authors: A M Stelken; L T Younis; S H Jennison; D D Miller; L W Miller; L J Shaw; D Kargl; B R Chaitman Journal: J Am Coll Cardiol Date: 1996-02 Impact factor: 24.094
Authors: Felipe X Cepeda; Edgar Toschi-Dias; Cristiane Maki-Nunes; Maria Urbana P B Rondon; Maria Janieire N N Alves; Ana Maria F W Braga; Daniel G Martinez; Luciano F Drager; Geraldo Lorenzi-Filho; Carlos E Negrao; Ivani C Trombetta Journal: Sleep Date: 2015-07-01 Impact factor: 5.849
Authors: Ricardo B Oliveira; Jonathan Myers; Claudio Gil S Araújo; Ross Arena; Sandra Mandic; Daniel Bensimhon; Joshua Abella; Paul Chase; Marco Guazzi; Peter Brubaker; Brian Moore; Dalane Kitzman; Mary Ann Peberdy Journal: Am J Cardiol Date: 2009-06-18 Impact factor: 2.778
Authors: Alberto Giannoni; Resham Baruah; Tora Leong; Michaela B Rehman; Luigi Emilio Pastormerlo; Frank E Harrell; Andrew J S Coats; Darrel P Francis Journal: PLoS One Date: 2014-01-27 Impact factor: 3.240
Authors: Janne Hulkkonen; Heikki Aatola; Kristiina Pälve; Terho Lehtimäki; Nina Hutri-Kähönen; Jorma Sa Viikari; Olli T Raitakari; Mika Kähönen Journal: BMC Cardiovasc Disord Date: 2014-03-13 Impact factor: 2.298