| Literature DB >> 9470165 |
D L McCaw1, M A Miller, P J Bergman, S J Withrow, A S Moore, D W Knapp, D Fowler, J C Johnson.
Abstract
Twenty-seven dogs with naturally occurring mast cell tumors were treated with weekly i.v. injections of vincristine (0.75 mg/m2) for 4 treatments. Two dogs (7%) had a partial response. Nine dogs (32%) had treatment stopped prematurely because of toxicity or a perceived deterioration in their quality of life. We conclude that vincristine is ineffective as a sole treatment for measurable mast cell tumors in dogs and produces an undesirable number of adverse reactions.Entities:
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Year: 1997 PMID： 9470165 DOI： 10.1111/j.1939-1676.1997.tb00484.x
Source DB: PubMed Journal: J Vet Intern Med ISSN： 0891-6640 Impact factor: 3.333