Literature DB >> 9469234

Behaviour therapy for obsessive-compulsive disorder: a decade of progress.

I Marks1.   

Abstract

OBJECTIVE: To review the last decade of behaviour therapy research in obsessive-compulsive disorder (OCD).
METHOD: The most salient research was analyzed.
RESULTS: Many studies confirmed that exposure and ritual prevention (ERP) effectively reduced compulsive rituals and obsessive thoughts in most patients in all age groups, although a minority of the patients did not complete treatment. Gains persisted to follow-up 2 to 6 years later in several countries. Improvement after ERP generalized to obsessive-compulsive beliefs, mood, work, and social adjustment, and was accompanied by reduction in cerebral blood flow in the right caudate nucleus. Teaching patients how to prevent relapse seems to reduce the risk of recurrence. ERP yields slightly more improvement than does appropriate antidepressant medication and is followed by far less relapse after treatment has stopped, so ERP may be more cost-effective in the long term. Antidepressant medication is a useful adjunct to ERP when OCD is accompanied by comorbid depression. The therapist now tends to teach patients how to carry out self-exposure and self-imposed ritual prevention, rather than to impose ERP on them. Self-help manuals help patients to do this, and computer aids to allow patients to learn how to do ERP at home have been valuable in pilot studies. Cognitive therapy without ERP was as useful as ERP.
CONCLUSION: ERP is of lasting value for OCD. Long-term cost-effectiveness comparisons are needed of self-administered ERP versus cognitive therapy and versus medication. Studies are also needed of brief psychological treatment for depression comorbid with OCD.

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Year:  1997        PMID: 9469234     DOI: 10.1177/070674379704201002

Source DB:  PubMed          Journal:  Can J Psychiatry        ISSN: 0706-7437            Impact factor:   4.356


  8 in total

1.  Stepped care for obsessive-compulsive disorder: An open trial.

Authors:  Christina M Gilliam; Gretchen J Diefenbach; Sara E Whiting; David F Tolin
Journal:  Behav Res Ther       Date:  2010-07-30

2.  Long-term course and outcome of obsessive-compulsive patients after cognitive-behavioral therapy in combination with either fluvoxamine or placebo: a 7-year follow-up of a randomized double-blind trial.

Authors:  Michael Rufer; Iver Hand; Heike Alsleben; Anne Braatz; Jürgen Ortmann; Birgit Katenkamp; Susanne Fricke; Helmut Peter
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2004-11-12       Impact factor: 5.270

3.  Unified protocol for the discontinuation of long-term serotonin reuptake inhibitors in obsessive compulsive disorder: Study protocol and methods.

Authors:  Christina L Boisseau; Steven A Rasmussen
Journal:  Contemp Clin Trials       Date:  2018-01-03       Impact factor: 2.226

4.  Clinical treatment of obsessive compulsive disorder.

Authors:  Christopher Pittenger; Ben Kelmendi; Michael Bloch; John H Krystal; Vladimir Coric
Journal:  Psychiatry (Edgmont)       Date:  2005-11

5.  Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control.

Authors:  H Szechtman; M J Eckert; W S Tse; J T Boersma; C A Bonura; J Z McClelland; K E Culver; D Eilam
Journal:  BMC Neurosci       Date:  2001-04-12       Impact factor: 3.288

6.  Mindfulness-based relapse prevention for substance use disorders: a pilot efficacy trial.

Authors:  Sarah Bowen; Neharika Chawla; Susan E Collins; Katie Witkiewitz; Sharon Hsu; Joel Grow; Seema Clifasefi; Michelle Garner; Anne Douglass; Mary E Larimer; Alan Marlatt
Journal:  Subst Abus       Date:  2009 Oct-Dec       Impact factor: 3.716

7.  Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder.

Authors:  S Saxena; E Gorbis; J O'Neill; S K Baker; M A Mandelkern; K M Maidment; S Chang; N Salamon; A L Brody; J M Schwartz; E D London
Journal:  Mol Psychiatry       Date:  2008-01-08       Impact factor: 15.992

8.  Decoding moral emotions in obsessive-compulsive disorder.

Authors:  Leonardo F Fontenelle; Ilana Frydman; Sebastian Hoefle; Ricardo Oliveira-Souza; Paula Vigne; Tiago S Bortolini; Chao Suo; Murat Yücel; Paulo Mattos; Jorge Moll
Journal:  Neuroimage Clin       Date:  2018-04-04       Impact factor: 4.881

  8 in total

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