Literature DB >> 9468594

Induction of apoptosis in human stomach cancer cells by green tea catechins.

H Hibasami1, T Komiya, Y Achiwa, K Ohnishi, T Kojima, K Nakanishi, K Akashi, Y Hara.   

Abstract

The exposure of human stomach cancer KATO III cells to green tea catechin extract and epigallocatechin gallate (EGCG), a main component of the extract led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological changes showing apoptotic body were observed in the cells treated with green tea catechin extract and EGCG. The fragmentation of DNA to oligonucleosomal-sized fragments, characteristic of apoptosis was determined to be concentration- and time-dependent. These data suggest that drinking of green tea in large amounts is recommended possibly to protect humans from stomach cancer.

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Year:  1998        PMID： 9468594     DOI： 10.3892/or.5.2.527

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   3.906


  10 in total

1.  Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population.

Authors:  Li-Na Mu; Qing-Yi Lu; Shun-Zhang Yu; Qing-Wu Jiang; Wei Cao; Nai-Chieh You; Veronica Wendy Setiawan; Xue-Fu Zhou; Bao-Guo Ding; Ru-Hong Wang; Jinkou Zhao; Lin Cai; Jian-Yu Rao; David Heber; Zuo-Feng Zhang
Journal:  Int J Cancer       Date:  2005-10-10       Impact factor: 7.396

2.  Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo.

Authors:  Phan L C H B Tran; Soo-A Kim; Hong Seok Choi; Jung-Hoon Yoon; Sang-Gun Ahn
Journal:  BMC Cancer       Date:  2010-06-10       Impact factor: 4.430

3.  Effect of storage temperature on the antioxidant activity and catechins stability of Matcha (Camellia sinensis).

Authors:  Jong Min Kim; Jin Yong Kang; Seon Kyeong Park; Hye Ju Han; Kyo-Yeon Lee; Ah-Na Kim; Jong Cheol Kim; Sung-Gil Choi; Ho Jin Heo
Journal:  Food Sci Biotechnol       Date:  2020-06-04       Impact factor: 2.391

4.  Apoptotic effect of Epigallocatechin-3-gallate on the human gastric cancer cell line MKN45 via activation of the mitochondrial pathway.

Authors:  Zhi-Hua Ran; Qi Xu; Jin-Lu Tong; Shu-Dong Xiao
Journal:  World J Gastroenterol       Date:  2007-08-21       Impact factor: 5.742

5.  EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells.

Authors:  Y D Jung; M S Kim; B A Shin; K O Chay; B W Ahn; W Liu; C D Bucana; G E Gallick; L M Ellis
Journal:  Br J Cancer       Date:  2001-03-23       Impact factor: 7.640

6.  Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients.

Authors:  H C Li; S Yashiki; J Sonoda; H Lou; S K Ghosh; J J Byrnes; C Lema; T Fujiyoshi; M Karasuyama; S Sonoda
Journal:  Jpn J Cancer Res       Date:  2000-01

7.  Mechanistic aspects of green tea as a cancer preventive: effect of components on human stomach cancer cell lines.

Authors:  S Okabe; Y Ochiai; M Aida; K Park; S J Kim; T Nomura; M Suganuma; H Fujiki
Journal:  Jpn J Cancer Res       Date:  1999-07

8.  Antioxidant and Anti-Melanogenesis Effects of Colloidal Gold Camellia sinensis L. Extracts.

Authors:  Seoyeon Shin; Minjeong Kim; Nuri Song; Sangouk Sun; Joonyong Choi; Kyungmok Park
Journal:  Molecules       Date:  2022-08-30       Impact factor: 4.927

9.  Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression.

Authors:  Jun-Ichiro Sonoda; Ryuji Ikeda; Yasutaka Baba; Keiko Narumi; Akio Kawachi; Erisa Tomishige; Kazuya Nishihara; Yasuo Takeda; Katsushi Yamada; Keizo Sato; Toshiro Motoya
Journal:  Exp Ther Med       Date:  2014-05-19       Impact factor: 2.447

Review 10.  Phytochemicals for the Prevention and Treatment of Gastric Cancer: Effects and Mechanisms.

Authors:  Qian-Qian Mao; Xiao-Yu Xu; Ao Shang; Ren-You Gan; Ding-Tao Wu; Atanas G Atanasov; Hua-Bin Li
Journal:  Int J Mol Sci       Date:  2020-01-16       Impact factor: 5.923
  10 in total

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