| Literature DB >> 9468051 |
M Vallet-Regí1, S Granado, D Arcos, M Gordo, M V Cabañas, C V Ragel, A J Salinas, A L Doadrio, J San Román.
Abstract
The preparation, characterization, and in vitro release of Ibuprofen from Al2O3, poly(L-lactic acid) (PLLA), and polymethylmethacrylate (PMMA) composites are described. The release process of the anti-inflammatory drug after the immersion of composites in a buffered solution is analyzed. The rate of Ibuprofen release is related to the crystalline or amorphous form of the drug. The presence of a ceramic component, alpha-Al2O3, and a biodegradable polymer, PLLA, facilitates both Ibuprofen crystallization and drug release. In addition, these composite systems modulate the release of the stereoisomers R(-) and S(+) of the drug.Entities:
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Year: 1998 PMID： 9468051 DOI： 10.1002/(sici)1097-4636(19980305)39:3<423::aid-jbm11>3.0.co;2-b
Source DB: PubMed Journal: J Biomed Mater Res ISSN： 0021-9304