G Lodi1, S R Porter. 1. Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, University of London, UK.
Abstract
OBJECTIVE: To review the current literature regarding the association of lichen planus (LP) and liver disease, with particular attention to the association of the oral variant of the disease with hepatitis C virus (HCV) infection. MATERIALS AND METHODS: Available literature of the possible association of LP with systemic disorders, in particular chronic hepatic disease, has been reviewed. RESULTS: LP is sometimes associated with infectious or autoimmune disease and/or neoplasia, however an aetiological association between LP and these disorders seems unlikely. A more consistent association exists between LP and chronic hepatic disease. The precise cause of this association is not known. However, in the last 6 years a notable association between HCV infection and LP has been observed, particularly in patients in Spain, Italy and Japan. The pathogenesis of this possible HCV-associated LP is not known, but it may involve a cell mediated response to an altered epithelial antigen. CONCLUSION: There is now evidence to suggest a significant association between HCV infection and LP in some groups of patients.
OBJECTIVE: To review the current literature regarding the association of lichen planus (LP) and liver disease, with particular attention to the association of the oral variant of the disease with hepatitis C virus (HCV) infection. MATERIALS AND METHODS: Available literature of the possible association of LP with systemic disorders, in particular chronic hepatic disease, has been reviewed. RESULTS: LP is sometimes associated with infectious or autoimmune disease and/or neoplasia, however an aetiological association between LP and these disorders seems unlikely. A more consistent association exists between LP and chronic hepatic disease. The precise cause of this association is not known. However, in the last 6 years a notable association between HCV infection and LP has been observed, particularly in patients in Spain, Italy and Japan. The pathogenesis of this possible HCV-associated LP is not known, but it may involve a cell mediated response to an altered epithelial antigen. CONCLUSION: There is now evidence to suggest a significant association between HCV infection and LP in some groups of patients.
Authors: Letícia Côgo Marques; Laiza Angela de Medeiros Nunes da Silva; Pâmella de Pinho Montovani Santos; Amanda de Almeida Lima Borba Lopes; Karin Soares Cunha; Adrianna Milagres; Rafaela Elvira Rozza-de-Menezes; Arley Silva Junior; Danielle Castex Conde Journal: Head Face Med Date: 2022-09-06 Impact factor: 2.246