| Literature DB >> 9467108 |
K Yamamoto1, K Makimura, T Sudo, K Shibuya, K Uchida, H Yamaguchi.
Abstract
Mice treated with cyclophosphamide were infected intravenously with titrated doses of Trichosporon asahii TIMM3140 or TIMM3144. Mortality and survival time correlated with inoculum size and fungal growth was found in the lung, heart, liver, spleen, kidney and brain. Fluconazole and amphotericin B prolonged survival time and reduced the CFU in the kidney, with fluconazole being superior to amphotericin B. The serum level of (1-->3)-beta-D-glucan was reduced by antifungal therapy and correlated well with the CFU/organ in kidney, but not CFU/ml in blood.Entities:
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Year: 1997 PMID： 9467108 DOI： 10.1080/02681219780001511
Source DB: PubMed Journal: J Med Vet Mycol ISSN： 0268-1218