Noradrenaline-mediated lateral inhibition in the sympathetic ganglion.

Intracellular recordings were made from neurons of denervated superior cervical ganglion (SCG) of the rat. Focal electrical stimulation near the recording site evoked a monosynaptic inhibitory postsynaptic potential (IPSP) in about 15% of SCG neurons. The IPSP was reversibly abolished by alpha2-adrenoceptor antagonist, yohimbine. The ionic mechanism of the IPSP appeared to be due to an increase of potassium conductance following the activation of alpha2-adrenoceptor. Electron microscopic observations confirmed that these cells received synapses of intrinsic type. It was concluded that some SCG neurons were under an inhibitory control from neighboring neurons via noradrenergic synapses.