Literature DB >> 9464240

Conformational effect of phosphorylation on T cell receptor/CD3 zeta-chain sequences.

I Laczkó1, M Hollósi, E Vass, Z Hegedüs, E Monostori, G K Tóth.   

Abstract

The effect of tyrosine-phosphorylation on the conformation of three tyrosine-based immunoreceptor activation motifs, zeta(69-86), zeta(106-126), and zeta(138-155), located in the T cell receptor/CD3 zeta-chain was investigated. Circular dichroism and Fourier-transform infrared spectroscopy of the nonphosphorylated and phosphorylated fragments gave evidence that phosphorylation can alter the secondary structure of the peptides. The most significant--alpha-helix to beta-sheet--conformational change was observed in the case of the zeta(138-155) peptide sequence which may be relevant to recognition by Src homology 2 (SH2) domains of signaling proteins.

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Year:  1998        PMID： 9464240     DOI： 10.1006/bbrc.1997.7989

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits.

Authors:  Alexander B Sigalov; Dikran A Aivazian; Vladimir N Uversky; Lawrence J Stern
Journal:  Biochemistry       Date:  2006-12-19       Impact factor: 3.162

2.  Membrane binding of intrinsically disordered proteins: Critical importance of an appropriate membrane model.

Authors:  Alexander B Sigalov
Journal:  Self Nonself       Date:  2010-02-17

3.  The SCHOOL of nature: II. Protein order, disorder and oligomericity in transmembrane signaling.

Authors:  Alexander B Sigalov
Journal:  Self Nonself       Date:  2010-02-22

4.  Membrane binding mode of intrinsically disordered cytoplasmic domains of T cell receptor signaling subunits depends on lipid composition.

Authors:  Alexander B Sigalov; Gregory M Hendricks
Journal:  Biochem Biophys Res Commun       Date:  2009-09-04       Impact factor: 3.575

5.  The cytosolic domain of T-cell receptor ζ associates with membranes in a dynamic equilibrium and deeply penetrates the bilayer.

Authors:  Kerstin Zimmermann; Rebecca Eells; Frank Heinrich; Stefanie Rintoul; Brian Josey; Prabhanshu Shekhar; Mathias Lösche; Lawrence J Stern
Journal:  J Biol Chem       Date:  2017-09-11       Impact factor: 5.157

6.  T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation.

Authors:  Ruth M Risueño; Wolfgang W A Schamel; Balbino Alarcón
Journal:  PLoS One       Date:  2008-03-05       Impact factor: 3.240
  6 in total

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