Y Gelfin1, M Gorfine, B Lerer. 1. Department of Psychiatry, Hadassah-Hebrew University Medical Center, Kiryat Hadassah-Ein Karem, Jerusalem, Israel.
Abstract
OBJECTIVE: The authors sought to determine the effect of clinically equivalent doses of fluoxetine on mood and other psychological variables in normal subjects. METHOD:Fifteen healthy volunteers received placebo for 2 weeks; fluoxetine, 10 mg/day, for 1 week; fluoxetine, 20 mg/day, for 5 weeks; and then an additional 2 weeks of placebo in the context of a single-blind study. The subjects were evaluated with a series of self- and observer-rated instruments. RESULTS: No significant effects attributable to fluoxetine were observed on any of the psychological variables examined. Minimal adverse effects were reported. CONCLUSIONS: Significant mood-elevating and other psychological effects of fluoxetine would appear to be induced only when symptomatic targets exist.
RCT Entities:
OBJECTIVE: The authors sought to determine the effect of clinically equivalent doses of fluoxetine on mood and other psychological variables in normal subjects. METHOD: Fifteen healthy volunteers received placebo for 2 weeks; fluoxetine, 10 mg/day, for 1 week; fluoxetine, 20 mg/day, for 5 weeks; and then an additional 2 weeks of placebo in the context of a single-blind study. The subjects were evaluated with a series of self- and observer-rated instruments. RESULTS: No significant effects attributable to fluoxetine were observed on any of the psychological variables examined. Minimal adverse effects were reported. CONCLUSIONS: Significant mood-elevating and other psychological effects of fluoxetine would appear to be induced only when symptomatic targets exist.
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