OBJECTIVE: The authors evaluated respiratory response to cholecystokinin tetrapeptide (CCK-4) in healthy volunteers. METHOD: Subjects were randomly assigned to either a CCK-4 (N = 15) or placebo (N = 15) challenge under double-blind conditions. RESULTS:Dyspnea was reported by all of the subjects who received CCK-4 but only one subject who received placebo. CCK-4 caused a significant increase in tidal volume and minute ventilation but had no effect on breathing frequency. Placebo had no effect on any of the respiratory measures. CONCLUSIONS: These data indicate that the behavioral effects of CCK-4 are accompanied by changes in respiration in healthy volunteers.
RCT Entities:
OBJECTIVE: The authors evaluated respiratory response to cholecystokinin tetrapeptide (CCK-4) in healthy volunteers. METHOD: Subjects were randomly assigned to either a CCK-4 (N = 15) or placebo (N = 15) challenge under double-blind conditions. RESULTS:Dyspnea was reported by all of the subjects who received CCK-4 but only one subject who received placebo. CCK-4 caused a significant increase in tidal volume and minute ventilation but had no effect on breathing frequency. Placebo had no effect on any of the respiratory measures. CONCLUSIONS: These data indicate that the behavioral effects of CCK-4 are accompanied by changes in respiration in healthy volunteers.
Authors: Richard J Maddock; Michael H Buonocore; Amber R Miller; Jong H Yoon; Steffan K Soosman; April M Unruh Journal: Biol Psychiatry Date: 2013-01-17 Impact factor: 13.382
Authors: Daniela Eser; Gregor Leicht; Jürgen Lutz; Stephan Wenninger; Valerie Kirsch; Cornelius Schüle; Susanne Karch; Thomas Baghai; Oliver Pogarell; Christine Born; Rainer Rupprecht; Christoph Mulert Journal: Hum Brain Mapp Date: 2009-02 Impact factor: 5.038
Authors: Daniela Eser; Cornelius Schüle; Thomas Baghai; Anette Floesser; Axel Krebs-Brown; Michaela Enunwa; Stephan de la Motte; Rolf Engel; Klaus Kucher; Rainer Rupprecht Journal: Psychopharmacology (Berl) Date: 2007-02-23 Impact factor: 4.415