Literature DB >> 9463573

Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114.

S Racca1, F Di Carlo, A Bartorelli, B Bussolati, G Bussolati.   

Abstract

A perchloric acid-soluble protein extracted from goat liver and designated as UK 114 is known to be expressed over the cell membrane of (some) human cancer cell lines. This protein is antigenic, and specific antibodies elicit complement-dependent cytolysis of neoplastic target cells. In this study we demonstrate that administration of UK 114, either pure or as a crude extract (designated UK 101), inhibits the growth of mammary carcinomas induced in female Sprague-Dawley rats by dimethylbenzanthracene (DMBA). The mechanism of the tumour inhibitory activity of UK 114 is probably related to induction of immunosurveillance.

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Year:  1997        PMID： 9463573     DOI： 10.1007/s004280050106

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


  5 in total

1.  Der f 34, a Novel Major House Dust Mite Allergen Belonging to a Highly Conserved Rid/YjgF/YER057c/UK114 Family of Imine Deaminases.

Authors:  Kareem Gamal ElRamlawy; Takashi Fujimura; Koji Baba; Ji Won Kim; Chika Kawamoto; Toshihide Isobe; Takuya Abe; Kelsey Hodge-Hanson; Diana M Downs; Inas Hussein Refaat; Diaa Beshr Al-Azhary; Tsunehiro Aki; Yoshiko Asaoku; Takaharu Hayashi; Takashi Katsutani; Shinji Tsuboi; Kazuhisa Ono; Seiji Kawamoto
Journal:  J Biol Chem       Date:  2016-08-18       Impact factor: 5.157

2.  Expression and in vitro anticancer activity of Lp16-PSP, a member of the YjgF/YER057c/UK114 protein family from the mushroom Lentinula edodes C91-3.

Authors:  Thomson Patrick Joseph; Qianqian Zhao; Warren Chanda; Sadia Kanwal; Yukun Fang; MinTao Zhong; Min Huang
Journal:  Arch Microbiol       Date:  2020-11-02       Impact factor: 2.552

3.  Recombinant perchloric acid-soluble protein suppresses the immunoglobulin production of human-human hybridoma HB4C5 cells.

Authors:  Hiroaki Kanouchi; Aya Matsuo; Tatsuzo Oka; Hirofumi Tachibana; Koji Yamada
Journal:  In Vitro Cell Dev Biol Anim       Date:  2003 Jul-Aug       Impact factor: 2.416

4.  Perchloric acid-soluble proteins from goat liver inhibit chemical carcinogenesis of Syrian hamster cheek-pouch carcinoma.

Authors:  F Ghezzo; G N Berta; B Bussolati; A Bosio; G Corvetti; F Di Carlo; G Bussolati; R Guglielmone; A Bartorelli
Journal:  Br J Cancer       Date:  1999-01       Impact factor: 7.640

5.  Members of the Rid protein family have broad imine deaminase activity and can accelerate the Pseudomonas aeruginosa D-arginine dehydrogenase (DauA) reaction in vitro.

Authors:  Kelsey M Hodge-Hanson; Diana M Downs
Journal:  PLoS One       Date:  2017-09-28       Impact factor: 3.240
  5 in total

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