AIMS: To evaluate the relation between Chlamydia trachomatis infection and stillbirth, placental tissue was studied for the presence of C trachomatis. METHODS: Paraffin wax embedded placental tissue of a stillbirth fetus, born at the 36th week of gestation to a 21 year old mother with high serum antibody titres to C trachomatis immunotypes during pregnancy and who was culture positive to C trachomatis three years previously, was studied by in situ hybridisation, polymerase chain reaction, and immunohistochemistry for the presence of C trachomatis. RESULTS: C trachomatis was detected in placental specimens by in situ hybridisation and alkaline phosphatase antialkaline phosphatase staining in several sections, whereas control tissues were uniformly negative, indicating the presence of C trachomatis nucleic acid and antigen in the placenta. CONCLUSION: This is the first reported case in which C trachomatis has been demonstrated in the human placenta.
AIMS: To evaluate the relation between Chlamydia trachomatis infection and stillbirth, placental tissue was studied for the presence of C trachomatis. METHODS:Paraffin wax embedded placental tissue of a stillbirth fetus, born at the 36th week of gestation to a 21 year old mother with high serum antibody titres to C trachomatis immunotypes during pregnancy and who was culture positive to C trachomatis three years previously, was studied by in situ hybridisation, polymerase chain reaction, and immunohistochemistry for the presence of C trachomatis. RESULTS: C trachomatis was detected in placental specimens by in situ hybridisation and alkaline phosphatase antialkaline phosphatase staining in several sections, whereas control tissues were uniformly negative, indicating the presence of C trachomatis nucleic acid and antigen in the placenta. CONCLUSION: This is the first reported case in which C trachomatis has been demonstrated in the human placenta.
Authors: M Puolakkainen; E Hiltunen-Back; T Reunala; S Suhonen; P Lähteenmäki; M Lehtinen; J Paavonen Journal: J Clin Microbiol Date: 1998-06 Impact factor: 5.948
Authors: Marian Kacerovsky; Roberto Romero; Lenka Pliskova; Radka Bolehovska; Helena Hornychova; Adela Matejkova; Hana Vosmikova; Ctirad Andrys; Martina Kolackova; Piotr Laudański; Vera Pelantova; Bo Jacobsson; Ivana Musilova Journal: J Matern Fetal Neonatal Med Date: 2019-07-15
Authors: G Ingrid J G Rours; Ronald R de Krijger; Alewijn Ott; Hendrina F M Willemse; Ronald de Groot; Luc J I Zimmermann; Renee F Kornelisse; Henri A Verbrugh; Roel P Verkooijen Journal: Eur J Epidemiol Date: 2011-03-24 Impact factor: 8.082