| Literature DB >> 9461665 |
H J Kim1, E R Woo, C G Shin, H Park.
Abstract
Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-O-(2",6"-O-digalloyl)-beta-D-galactopyranoside (1), together with six known flavonol glycosides and three known phenolic compounds. The structure of the new compound was determined by spectroscopic methods. The most active compounds were quercetin 3-O-(2"-galloyl)-alpha-L-arabinopyranoside (6) and 1, which exhibited IC50 values of 18.1 +/- 1.3 and 24.2 +/- 6.6 micrograms/mL, respectively, against HIV-1 integrase.Entities:
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Year: 1998 PMID： 9461665 DOI： 10.1021/np970171q
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050