Methodological analysis in behavioral toxicology: an ethotoxicological approach.

A constraint in the development of laboratory animal models of human disease conditions is their applicability to the natural environment in which a given animal species evolved. The range of behavioral patterns that can be carefully assessed and quantified in the laboratory is sometimes limited. Although field studies reflect behavioral responses in natural settings, they may also have methodological limitations. Laboratory techniques are not applicable to wild species since natural conditions cannot be brought into a laboratory in an inexpensive or reliable way. However, it is possible to create near-natural settings which may not fulfill all the criteria of the actual context of evolution, but which can be controlled by the experimenter. We recommend an integrative style of approach considering laboratory constraints and, at the same time, the ecological niche in which a given behavioral pattern evolved. This type of ethological assessment may be useful when carrying out toxicological studies on both wild and laboratory mammals.