| Literature DB >> 9458350 |
R Suto1, Y Abe, M Nakamura, Y Ohnishi, M Yoshimura, Y H Lee, T Imanishi, H Yamazaki, H Kijima, T Tokunaga, Y Oshika, N Hiraoka, N Tamaoki, H Fukuda, Y Ueyama.
Abstract
We examined the expression levels of P-glycoprotein (P-Gp)/the human multidrug resistance gene (MDR1) and in vivo chemosensitivity in the 7 osteosarcoma xenografts. Three of seven (43%) osteosarcoma xenografts expressed MDR1 by reverse transcriptase-polymerase chain reaction (RT-PCR). The OSS-516R xenograft selected with vincristine (VCR) from the MDR1-negative xenograft OSS-516, which was sensitive to VCR and doxorubicin (DOX), acquired cross-resistance to DOX. In the OSS-516R, RT-PCR assay showed definite MDR1 expression and immunohistochemical analysis demonstrated P-Gp-positive tumor cells. These results suggest that P-Gp/MDR1 overexpression is related to multidrug resistance in human osteosarcoma in vivo.Entities:
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Year: 1998 PMID： 9458350
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650