OBJECTIVE: To determine the accumulated end organ damage and health status in patients with SS and to compare with patients with SLE (with or without SS). METHODS: Thirty-seven patients with primary SS were studied and compared with 120 patients with SLE and 21 patients with SLE and SS. The Medical Outcome Survey Short Form 20 with an additional question for fatigue was used to assess health status. The SLICC/ACR damage index with a supplementary oral section was used to assess end organ damage. For statistical analysis, logistic regression analysis, Fisher's exact test, and Kruskal-Wallis rank tests were applied. RESULTS: Patients in all 3 groups had reduced quality of life with respect to all aspects of functional status and well being. There was no difference between the groups. In the primary SS group, the greatest damage was in the oral section (62% of patients). The patients with SLE and SS had the greatest renal, peripheral vascular, and musculoskeletal damage (24, 19, 38% of patients, respectively) followed by the SLE group. Ocular damage was more common in the primary SS group, but that was due to older age in this group. Malignancy was most common in the primary SS group (11%). Other organ damage scores did not differ between groups. CONCLUSION: End organ damage is uncommon in primary SS (with the exception of oral damage), but the degree of functional ability is as great as in SLE.
OBJECTIVE: To determine the accumulated end organ damage and health status in patients with SS and to compare with patients with SLE (with or without SS). METHODS: Thirty-seven patients with primary SS were studied and compared with 120 patients with SLE and 21 patients with SLE and SS. The Medical Outcome Survey Short Form 20 with an additional question for fatigue was used to assess health status. The SLICC/ACR damage index with a supplementary oral section was used to assess end organ damage. For statistical analysis, logistic regression analysis, Fisher's exact test, and Kruskal-Wallis rank tests were applied. RESULTS:Patients in all 3 groups had reduced quality of life with respect to all aspects of functional status and well being. There was no difference between the groups. In the primary SS group, the greatest damage was in the oral section (62% of patients). The patients with SLE and SS had the greatest renal, peripheral vascular, and musculoskeletal damage (24, 19, 38% of patients, respectively) followed by the SLE group. Ocular damage was more common in the primary SS group, but that was due to older age in this group. Malignancy was most common in the primary SS group (11%). Other organ damage scores did not differ between groups. CONCLUSION: End organ damage is uncommon in primary SS (with the exception of oral damage), but the degree of functional ability is as great as in SLE.
Authors: Frederick B Vivino; Steven E Carsons; Gary Foulks; Troy E Daniels; Ann Parke; Michael T Brennan; S Lance Forstot; R Hal Scofield; Katherine M Hammitt Journal: Rheum Dis Clin North Am Date: 2016-08 Impact factor: 2.670
Authors: Konstantinos Kotsis; Paraskevi V Voulgari; Niki Tsifetaki; Alexandros A Drosos; André F Carvalho; Thomas Hyphantis Journal: Rheumatol Int Date: 2014-04-27 Impact factor: 2.631
Authors: Michal Feldon; Payam Noroozi Farhadi; Hermine I Brunner; Lukasz Itert; Bob Goldberg; Abdullah Faiq; Jesse Wilkerson; Kathryn M Rose; Lisa G Rider; Frederick W Miller; Edward H Giannini Journal: Arthritis Care Res (Hoboken) Date: 2017-09-21 Impact factor: 4.794
Authors: Barbara Segal; Simon J Bowman; Philip C Fox; Frederick B Vivino; Nandita Murukutla; Jeff Brodscholl; Sarika Ogale; Lachy McLean Journal: Health Qual Life Outcomes Date: 2009-05-27 Impact factor: 3.186