Literature DB >> 9456017

Cutaneous necrotizing vasculitis after low dose methotrexate therapy for rheumatoid arthritis: a possible manifestation of methotrexate hypersensitivity.

T Simonart1, P Durez, J Margaux, J Van Geertruyden, D Goldschmidt, D Parent.   

Abstract

Large haemorrhagic and necrotic cutaneous lesions developed after two low dose (5 mg) methotrexate injections in a patient suffering from long standing rheumatoid arthritis. Differential clinical diagnosis included factitia dermatitis, infectious processes, pyoderma gangrenosum, rheumatoid neutrophilic dermatitis, necrotizing arteritis and vasculitis. Histological and direct immunofluorescent examinations of skin biopsies supported the diagnosis of leucocytoclastic vasculitis. We discuss the respective roles of methotrexate and rheumatoid arthritis in the outbreak of leucocytoclastic vasculitis. Hypersensitivity is strongly suspected.

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Year:  1997        PMID： 9456017     DOI： 10.1007/bf02247805

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  11 in total

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Journal:  Arthritis Rheum       Date:  1976 Sep-Oct

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Journal:  Therapie       Date:  1985 Mar-Apr       Impact factor: 2.070

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Authors:  M K Lindsay; H B Tavadia; A S Whyte; P Lee; J Webb
Journal:  Br Med J       Date:  1973-06-09

Review 7.  Urticarial vasculitis: a histopathologic and clinical review of 72 cases.

Authors:  D R Mehregan; M J Hall; L E Gibson
Journal:  J Am Acad Dermatol       Date:  1992-03       Impact factor: 11.527

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Authors:  P V Harrison
Journal:  Br J Dermatol       Date:  1987-06       Impact factor: 9.302

9.  Rheumatoid neutrophilic dermatitis.

Authors:  J L Sánchez; A Cruz
Journal:  J Am Acad Dermatol       Date:  1990-05       Impact factor: 11.527

10.  Long-term prospective study of methotrexate in the treatment of rheumatoid arthritis. 84-month update.

Authors:  M E Weinblatt; B N Weissman; D E Holdsworth; P A Fraser; A L Maier; K R Falchuk; J S Coblyn
Journal:  Arthritis Rheum       Date:  1992-02
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  1 in total

1.  Improved rheumatoid digital vasculitis in a patient treated with TNFalpha agent blocking (infliximab).

Authors:  Maurizio Benucci; Francesca Li Gobbi; Gianantonio Saviola; Mariangela Manfredi
Journal:  Rheumatol Int       Date:  2008-05-21       Impact factor: 2.631
  1 in total

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