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Literature DB >> 9455893

A monoclonal antibody specific to surface antigen on Candida krusei.

R Robert¹, O Faure, A Carloti, B Lebeau, C Bernard, A Marot-Leblond, R Grillot, J M Senet.

Abstract

A monoclonal antibody (MAb; MAb 6B3) which reacts specifically with a cell wall antigen found in all strains or isolates of Candida krusei was developed. MAb 6B3 was extensively tested by immunofluorescence assay for cross-reaction with many Candida, Cryptococcus, Saccharomyces, Trichosporon, and Rhodotorula species and was found to react only with the species C. krusei. The specific epitope is expressed on the surface of fungal cells and appears to reside on a protein moiety. Taking into account the increasing importance of fluconazole-resistant strains in nosocomial fungal infections, the very high degree of specificity of this MAb for C. krusei could be useful for the routine detection of C. krusei in culture or in tissue samples.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1998 PMID： 9455893 PMCID： PMC121404 DOI： 10.1128/CDLI.5.1.121-124.1998

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

24 in total

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