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Literature DB >> 9453638

Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice.

G Fragoso¹, E Lamoyi, A Mellor, C Lomelí, M Hernández, E Sciutto.

Abstract

We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps, whereas BALB/cJ expresses Qa-2 and is highly resistant. In this study, we investigated the role of Qa-2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN x (C57BL/6J x BALB/cAnN)F1 and BALB/cAnN x (BALB/cJ x BALB/cAnN)F1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites were recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9453638 PMCID： PMC107967

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

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7. Characterization of S3Pvac anti-cysticercosis vaccine components: implications for the development of an anti-cestodiasis vaccine.

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