Literature DB >> 945258

Pleuromutilins. Fermentation, structure and biosynthesis.

F Knauseder, E Brandl.   

Abstract

Derivatives of pleuromutilin, formed during the fermentation of pleuromutilin, were isolated and their structure determined. 14-Acetyl-mutilin and mutilin as well as different unsaturated fatty acid esters of pleuromutilin were identified. The proportion of each derivative formed depends to a considerable degree on the conditions of the fermentation process. The possible biosynthetic pathways are shown.

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Year:  1976        PMID： 945258     DOI： 10.7164/antibiotics.29.125

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  A concise synthesis of the molecular framework of pleuromutilin.

Authors:  Junjia Liu; Stephen D Lotesta; Erik J Sorensen
Journal:  Chem Commun (Camb)       Date:  2010-11-16       Impact factor: 6.222

2.  Design and Synthesis of Molecular Scaffolds with Anti-infective Activity.

Authors:  Junjia Liu; T Aaron Bedell; Julian G West; Erik J Sorensen
Journal:  Tetrahedron       Date:  2016-01-28       Impact factor: 2.457

3.  Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

Authors:  Ranjala Ratnayake; David Covell; Tanya T Ransom; Kirk R Gustafson; John A Beutler
Journal:  Org Lett       Date:  2009-01-01       Impact factor: 6.005

4.  Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives.

Authors:  Fabrizio Alberti; Khairunisa Khairudin; Edith Rodriguez Venegas; Jonathan A Davies; Patrick M Hayes; Christine L Willis; Andy M Bailey; Gary D Foster
Journal:  Nat Commun       Date:  2017-11-28       Impact factor: 14.919

Review 5.  An Annotated Inventory of Tanzanian Medicinal Plants Traditionally Used for the Treatment of Respiratory Bacterial Infections.

Authors:  Ester Innocent; Alphonce Ignace Marealle; Peter Imming; Lucie Moeller
Journal:  Plants (Basel)       Date:  2022-03-30

6.  Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production.

Authors:  Andy M Bailey; Fabrizio Alberti; Sreedhar Kilaru; Catherine M Collins; Kate de Mattos-Shipley; Amanda J Hartley; Patrick Hayes; Alison Griffin; Colin M Lazarus; Russell J Cox; Christine L Willis; Karen O'Dwyer; David W Spence; Gary D Foster
Journal:  Sci Rep       Date:  2016-05-04       Impact factor: 4.379
  6 in total

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