Literature DB >> 9452398

Proteases of malaria parasites: new targets for chemotherapy.

P J Rosenthal1.   

Abstract

The increasing resistance of malaria parasites to antimalarial drugs is a major contributor to the reemergence of the disease as a major public health problem and its spread in new locations and populations. Among potential targets for new modes of chemotherapy are malarial proteases, which appear to mediate processes within the erythrocytic malarial life cycle, including the rupture and invasion of infected erythrocytes and the degradation of hemoglobin by trophozoites. Cysteine and aspartic protease inhibitors are now under study as potential antimalarials. Lead compounds have blocked in vitro parasite development at nanomolar concentrations and cured malaria-infected mice. This review discusses available antimalarial agents and summarizes experimental results that support development of protease inhibitors as antimalarial drugs.

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Year:  1998        PMID： 9452398      PMCID： PMC2627653          DOI： 10.3201/eid0401.980107

Source DB:  PubMed          Journal:  Emerg Infect Dis        ISSN： 1080-6040            Impact factor:   6.883


  68 in total

1.  The effect of insecticide-treated bed nets on mortality of Gambian children.

Authors:  P L Alonso; S W Lindsay; J R Armstrong; M Conteh; A G Hill; P H David; G Fegan; A de Francisco; A J Hall; F C Shenton
Journal:  Lancet       Date:  1991-06-22       Impact factor: 79.321

2.  A role for erythrocyte band 3 degradation by the parasite gp76 serine protease in the formation of the parasitophorous vacuole during invasion of erythrocytes by Plasmodium falciparum.

Authors:  E Roggwiller; M E Bétoulle; T Blisnick; C Braun Breton
Journal:  Mol Biochem Parasitol       Date:  1996-11-12       Impact factor: 1.759

Review 3.  Systematic review of amodiaquine treatment in uncomplicated malaria.

Authors:  P Olliaro; C Nevill; J LeBras; P Ringwald; P Mussano; P Garner; P Brasseur
Journal:  Lancet       Date:  1996-11-02       Impact factor: 79.321

4.  Standard and reduced doses of sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum in Tanzania, with determination of drug concentrations and susceptibility in vitro.

Authors:  U Hellgren; C M Kihamia; Y Bergqvist; M Lebbad; Z Premji; L Rombo
Journal:  Trans R Soc Trop Med Hyg       Date:  1990 Jul-Aug       Impact factor: 2.184

5.  Plasmodium falciparum: isolation and characterization of a 55-kDa protease with a cathepsin D-like activity from P. falciparum.

Authors:  E Bailly; J Savel; G Mahouy; G Jaureguiberry
Journal:  Exp Parasitol       Date:  1991-04       Impact factor: 2.011

6.  Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.

Authors:  A M Silva; A Y Lee; S V Gulnik; P Maier; J Collins; T N Bhat; P J Collins; R E Cachau; K E Luker; I Y Gluzman; S E Francis; A Oksman; D E Goldberg; J W Erickson
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

7.  A new blood stage antigen of Plasmodium falciparum highly homologous to the serine-stretch protein SERP.

Authors:  B Knapp; U Nau; E Hundt; H A Küpper
Journal:  Mol Biochem Parasitol       Date:  1991-01       Impact factor: 1.759

8.  Peptide derivatives specific for a Plasmodium falciparum proteinase inhibit the human erythrocyte invasion by merozoites.

Authors:  R Mayer; I Picard; P Lawton; P Grellier; C Barrault; M Monsigny; J Schrével
Journal:  J Med Chem       Date:  1991-10       Impact factor: 7.446

9.  Vivax malaria resistant to treatment and prophylaxis with chloroquine.

Authors:  G S Murphy; H Basri; E M Andersen; M J Bangs; D L Mount; J Gorden; A A Lal; A R Purwokusumo; S Harjosuwarno
Journal:  Lancet       Date:  1993-01-09       Impact factor: 79.321

10.  Iron chelation as a chemotherapeutic strategy for falciparum malaria.

Authors:  V R Gordeuk; P E Thuma; G M Brittenham; G Biemba; S Zulu; G Simwanza; P Kalense; A M'Hango; D Parry; A A Poltera
Journal:  Am J Trop Med Hyg       Date:  1993-02       Impact factor: 2.345
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  25 in total

1.  Looking for the exit: How do malaria parasites escape from red blood cells?

Authors:  L H Bannister
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-16       Impact factor: 11.205

2.  Serine protease inhibitors block invasion of host cells by Toxoplasma gondii.

Authors:  V Conseil; M Soête; J F Dubremetz
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

3.  Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies.

Authors:  Yogesh A Sabnis; Prashant V Desai; Philip J Rosenthal; Mitchell A Avery
Journal:  Protein Sci       Date:  2003-03       Impact factor: 6.725

4.  Expression and characterization of catalytic domain of Plasmodium falciparum subtilisin-like protease 3.

Authors:  Asrar Alam; Raj K Bhatnagar; Virander S Chauhan
Journal:  Mol Biochem Parasitol       Date:  2012-01-20       Impact factor: 1.759

5.  Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite.

Authors:  Yimin Wu; Xiangyun Wang; Xia Liu; Yufeng Wang
Journal:  Genome Res       Date:  2003-04       Impact factor: 9.043

Review 6.  Chemical biology approaches for the study of apicomplexan parasites.

Authors:  Matthew A Child
Journal:  Mol Biochem Parasitol       Date:  2013-12-11       Impact factor: 1.759

Review 7.  Sequence, Structural Analysis and Metrics to Define the Unique Dynamic Features of the Flap Regions Among Aspartic Proteases.

Authors:  Lara McGillewie; Muthusamy Ramesh; Mahmoud E Soliman
Journal:  Protein J       Date:  2017-10       Impact factor: 2.371

8.  Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria.

Authors:  Xuerong Li; Huiqing Chen; Noemi Bahamontes-Rosa; Jurgen F J Kun; Boubacar Traore; Peter D Crompton; Athar H Chishti
Journal:  Biochem Biophys Res Commun       Date:  2009-01-25       Impact factor: 3.575

9.  Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum.

Authors:  Subash Chandra Mohapatra; Hemandra Kumar Tiwari; Manisha Singla; Brijesh Rathi; Arun Sharma; Kuldeep Mahiya; Mukesh Kumar; Saket Sinha; Shyam Singh Chauhan
Journal:  J Biol Inorg Chem       Date:  2009-11-28       Impact factor: 3.358

10.  The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L.

Authors:  Bailey Miller; Aaron J Friedman; Hyukjae Choi; James Hogan; J Andrew McCammon; Vivian Hook; William H Gerwick
Journal:  J Nat Prod       Date:  2013-12-23       Impact factor: 4.050
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