Literature DB >> 9450690

Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia.

A L Oaklander1, A J Belzberg.   

Abstract

Injury makes sensory neurons abnormally excitable and triggers coincident alterations in relative levels of different types of voltage-gated sodium channels that they express. We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.

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Year:  1997        PMID： 9450690     DOI： 10.1016/s0169-328x(97)00239-8

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  10 in total

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  10 in total

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