OBJECTIVE: To evaluate the effect of albendazole combined with surgery on the incidence of recurrent hydatid disease. DESIGN: Prospective open study. SETTING: Teaching hospital, Turkey. SUBJECTS: 25 patients who presented with hepatic hydatid disease between December 1992 and October 1995. INTERVENTIONS: Albendazole 10 mg/kg/day for a month before ultrasonography and then excision, and then albendazole for a further two months. RESULTS: 2 patients were excluded because the albendazole caused disturbance of liver enzyme activities. Of the remaining 23 patients only 7 had viable cysts on ultrasonography. In 15 patients (65%) the germinal layer was partially or totally destroyed, and in 15 the fluid was either cloudy or stained with bile. During a mean follow up period of 29 months only one patient developed recurrent disease. CONCLUSION: Perioperative treatment with albendazole resulted in fewer recurrences than expected. A longer preoperative period of treatment may increase the success rate; this requires further study.
OBJECTIVE: To evaluate the effect of albendazole combined with surgery on the incidence of recurrent hydatid disease. DESIGN: Prospective open study. SETTING: Teaching hospital, Turkey. SUBJECTS: 25 patients who presented with hepatic hydatid disease between December 1992 and October 1995. INTERVENTIONS:Albendazole 10 mg/kg/day for a month before ultrasonography and then excision, and then albendazole for a further two months. RESULTS: 2 patients were excluded because the albendazole caused disturbance of liver enzyme activities. Of the remaining 23 patients only 7 had viable cysts on ultrasonography. In 15 patients (65%) the germinal layer was partially or totally destroyed, and in 15 the fluid was either cloudy or stained with bile. During a mean follow up period of 29 months only one patient developed recurrent disease. CONCLUSION: Perioperative treatment with albendazole resulted in fewer recurrences than expected. A longer preoperative period of treatment may increase the success rate; this requires further study.
Authors: Concepción Gomez I Gavara; Rafael López-Andújar; Tatiana Belda Ibáñez; José M Ramia Ángel; Ángel Moya Herraiz; Francisco Orbis Castellanos; Eugenia Pareja Ibars; Fernando San Juan Rodríguez Journal: World J Gastroenterol Date: 2015-01-07 Impact factor: 5.742