| Literature DB >> 9449433 |
L Dong-Ryul1, H Kondo, S Furukawa, K Nakano.
Abstract
Effects of various amino acids and tryptophan metabolites on the synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells were evaluated. L-Tryptophan stimulated NGF production in a dose-dependent manner. Serotonin and quinolinic acid slightly increased NGF synthesis. L-Kynurenine had a marked stimulatory effect on NGF production at a dose of 10 microM. In contrast, kynurenic acid had no effect on the reaction. L-Glutamine, L-glutamic acid, L-phenylalanine and L-methionine produced no significant change in NGF synthesis. These results were discussed in relation to the treatment of Alzheimer's diseases.Entities:
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Year: 1997 PMID： 9449433 DOI： 10.1016/s0006-8993(97)01164-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252