Literature DB >> 9449431

Increased seizure susceptibility in adult rats with neuronal migration disorders.

I M Germano1, E F Sperber.   

Abstract

Recent data show that neuronal migration disorders (NMD) lower the seizure threshold in the immature brain. To assess if this is an age-related phenomenon, kainic acid (KA) was administered to induce status epilepticus in adult rats with NMD. Results of the present study demonstrate that adult rats with NMD had a shorter latency to seizures and longer duration of status epilepticus compared to age-related controls. Furthermore, in rats with NMD seizures were more severe and status epilepticus-induced mortality was worse than in age-matched controls. These data confirm that NMD lower the seizure threshold in the adult rat. The results of the present study combined with our previous studies in the immature rat, suggest that the facilitating effects of NMD on seizures are not age dependent.

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Year:  1997        PMID： 9449431     DOI： 10.1016/s0006-8993(97)01022-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Initiation of epileptiform activity in a rat model of periventricular nodular heterotopia.

Authors:  Naranzogt Tschuluun; H Jürgen Wenzel; Emily T Doisy; Philip A Schwartzkroin
Journal:  Epilepsia       Date:  2011-09-20       Impact factor: 5.864

2.  Abnormal morphological and functional organization of the hippocampus in a p35 mutant model of cortical dysplasia associated with spontaneous seizures.

Authors:  H J Wenzel; C A Robbins; L H Tsai; P A Schwartzkroin
Journal:  J Neurosci       Date:  2001-02-01       Impact factor: 6.167

3.  Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy.

Authors:  P A Castro; E C Cooper; D H Lowenstein; S C Baraban
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

4.  Rapamycin Cannot Reduce Seizure Susceptibility in Infantile Rats with Malformations of Cortical Development Lacking mTORC1 Activation.

Authors:  Minyoung Lee; Eun-Jin Kim; Min-Jee Kim; Mi-Sun Yum
Journal:  Mol Neurobiol       Date:  2022-10-04       Impact factor: 5.682

5.  Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex.

Authors:  N Chevassus-Au-Louis; P Congar; A Represa; Y Ben-Ari; J L Gaïarsa
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

6.  Dampened hippocampal oscillations and enhanced spindle activity in an asymptomatic model of developmental cortical malformations.

Authors:  Elena Cid; Daniel Gomez-Dominguez; David Martin-Lopez; Beatriz Gal; François Laurent; Jose M Ibarz; Fiona Francis; Liset Menendez de la Prida
Journal:  Front Syst Neurosci       Date:  2014-04-14

7.  A New Rat Model of Epileptic Spasms Based on Methylazoxymethanol-Induced Malformations of Cortical Development.

Authors:  Eun-Hee Kim; Mi-Sun Yum; Minyoung Lee; Eun-Jin Kim; Woo-Hyun Shim; Tae-Sung Ko
Journal:  Front Neurol       Date:  2017-06-12       Impact factor: 4.003

8.  Atypical febrile seizures, mesial temporal lobe epilepsy, and dual pathology.

Authors:  Nathalie T Sanon; Sébastien Desgent; Lionel Carmant
Journal:  Epilepsy Res Treat       Date:  2012-04-23
  8 in total

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