Literature DB >> 944933

A dose-response comparison between methadone and morphine self-administration.

T E Werner, S G Smith, W M Davis.   

Abstract

Rats were allowed to self-administer a solution of 0.9% saline, or 0.01, 0.03, 0.1 or 0.3 mg/kg/infusion of methadone hydrochloride or 0.03, 0.1 or 0.3 mg/kg/infusion of morphine sulfate. The results showed that number of infusions taken was an inverse function of unit dose, while amount of drug self-administered (mg/kg) was a direct function of unit dose. The data also indicated that more morphine than methadone was self-administered.

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Year:  1976        PMID： 944933     DOI： 10.1007/bf00735825

Source DB:  PubMed          Journal:  Psychopharmacologia


  5 in total

1.  ANALGESIC ACTION AND BRAIN AND PLASMA LEVELS OF MORPHINE AND CODEINE IN MORPHINE TOLERANT, CODEINE TOLERANT AND NON-TOLERANT RATS.

Authors:  T JOHANNESSON; L A WOODS
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1964

2.  RELATIVE POTENCY OF CODEINE, METHADONE AND DIHYDROMORPHINONE TO MORPHINE IN SELF-MAINTAINED ADDICT RATS.

Authors:  R J COLLINS; J R WEEKS
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1965-01-08

3.  Observations on the comparative pharmacologic actions of 6-dimethylamino-4,4-diphenyl-3-heptanone (amidone) and morphine.

Authors:  J K FINNEGAN; H B HAAG
Journal:  J Pharmacol Exp Ther       Date:  1948-03       Impact factor: 4.030

4.  Physiological disposition and metabolism of levo-methadone-1- 3 H in nontolerant and tolerant rats.

Authors:  A L Misra; S J Mulé; R Bloch; N L Vadlamani
Journal:  J Pharmacol Exp Ther       Date:  1973-05       Impact factor: 4.030

5.  Stereoselectivity and differential metabolism in vivo of dextro and laevo-methadone-1- 3 H.

Authors:  A L Misra; S J Mulè
Journal:  Nature       Date:  1973-01-26       Impact factor: 49.962
  5 in total
  5 in total

1.  Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids.

Authors:  Ning-Sheng Cai; César Quiroz; Jordi Bonaventura; Alessandro Bonifazi; Thomas O Cole; Julia Purks; Amy S Billing; Ebonie Massey; Michael Wagner; Eric D Wish; Xavier Guitart; William Rea; Sherry Lam; Estefanía Moreno; Verònica Casadó-Anguera; Aaron D Greenblatt; Arthur E Jacobson; Kenner C Rice; Vicent Casadó; Amy H Newman; John W Winkelman; Michael Michaelides; Eric Weintraub; Nora D Volkow; Annabelle M Belcher; Sergi Ferré
Journal:  J Clin Invest       Date:  2019-03-26       Impact factor: 14.808

2.  Orally delivered methadone as a reinforcer in rhesus monkeys.

Authors:  R B Stewart; J Grabowski; N S Wang; R A Meisch
Journal:  Psychopharmacology (Berl)       Date:  1996-01       Impact factor: 4.530

Review 3.  Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.

Authors:  Chloe J Jordan; Jianjing Cao; Amy Hauck Newman; Zheng-Xiong Xi
Journal:  Neuropharmacology       Date:  2019-04-19       Impact factor: 5.250

4.  Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats.

Authors:  H O Pettit; A Ettenberg; F E Bloom; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

5.  Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems.

Authors:  A Ettenberg; H O Pettit; F E Bloom; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530
  5 in total

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