Literature DB >> 944913

Effects of hypercalcemia on water and sodium excretion by the isolated dog kidney.

J L Vanherweghem, J Ducobu, A d'Hollander, C Toussaint.   

Abstract

The effects of acute hypercalcemia on hemodynamics and on water and sodium excretion were studied on the blood-perfused isolated dog kidney. This model advantageously eliminates various factors which modify medullary osmolality and intrarenal hemodynamics, as well as collecting duct permeability. Calcium ion directly inhibits sodium reabsorption in the proximal tubule and in the ascending limb of Henle's loop, leading to increased sodium excretion rate and to decreased free water generation. The vasoconstrictive action of calcium, leading to decreased glomerular filtration rate, may mitigate the strong natriuretic effect of this ion.

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Year:  1976        PMID： 944913     DOI： 10.1007/bf00587405

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  38 in total

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Authors:  P S CHEN; W F NEUMAN
Journal:  Am J Physiol       Date:  1955-03

2.  Effect of intravenous infusions of calcium on renal concentrating ability.

Authors:  D BECK; H LEVITIN; F H EPSTEIN
Journal:  Am J Physiol       Date:  1959-11

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Authors:  H D Itskovitz; J Stemper; D Pacholczyk; J C McGiff
Journal:  Clin Sci Mol Med Suppl       Date:  1973-08

4.  Effects of potassium depletion on renal tubular sodium and water reabsorption in the dog.

Authors:  B Rosenbaum; M J Kinney; F C Scudder; V A DiScala; R M Stein
Journal:  Am J Physiol       Date:  1972-04

5.  [Effect of an intravenous infusion of calcium on the mechanism of urinary concentration].

Authors:  J P Guignard; M A Barraclough; N F Jones
Journal:  Helv Physiol Pharmacol Acta       Date:  1968

Review 6.  Concentration of urine in the mammalian kidney.

Authors:  R W Berliner; C M Bennett
Journal:  Am J Med       Date:  1967-05       Impact factor: 4.965

7.  Effect of hypercalcemia on renal tubular sodium handling in the rat.

Authors:  G F DiBona
Journal:  Am J Physiol       Date:  1971-01

8.  Functional capacity of the isolated perfused dog kidney.

Authors:  A Nizet; Y Cuypers; P Deetjen; K Kramer
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1967

9.  Mechanism of glomerulotubular balance. I. Effect of aortic constriction and elevated ureteropelvic pressure on glomerular filtration rate, fractional reabsorption, transit time, and tubular size in the proximal tubule of the rat.

Authors:  F C Rector; F P Brunner; D W Seldin
Journal:  J Clin Invest       Date:  1966-04       Impact factor: 14.808

10.  The effect of Ca and antidiuretic hormone on Na transport across frog skin. II. Sites and mechanisms of action.

Authors:  P F CURRAN; F C HERRERA; W J FLANIGAN
Journal:  J Gen Physiol       Date:  1963-05       Impact factor: 4.086
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  4 in total

1.  Renal electrolyte excretion and renin release during calcium and parathormone infusions in conscious rabbits.

Authors:  W S Peart; S A Roddis; R J Unwin
Journal:  J Physiol       Date:  1986-04       Impact factor: 5.182

2.  Control of renal hemodynamics and glomerular filtration rate in chronic hypercalcemia. Role of prostaglandins, renin-angiotensin system, and calcium.

Authors:  M Levi; M A Ellis; T Berl
Journal:  J Clin Invest       Date:  1983-06       Impact factor: 14.808

3.  Evidence for a parathyroid hormone-dependent influence of calcium on the glomerular ultrafiltration coefficient.

Authors:  H D Humes; I Ichikawa; J L Troy; B M Brenner
Journal:  J Clin Invest       Date:  1978-01       Impact factor: 14.808

4.  Effect of zinc supplementation on chronic hepatorenal toxicity following oral exposure to glyphosate-based herbicide (Bushfire®) in rats.

Authors:  Emmanuel Vandi Tizhe; Najume Dogon-Giginya Ibrahim; Mohammed Yakasai Fatihu; Suleiman Folorunsho Ambali; Ikechukwu Onyebuchi Igbokwe; Ussa Delia Tizhe
Journal:  J Int Med Res       Date:  2020-08       Impact factor: 1.671
  4 in total

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