Literature DB >> 9449034

Role of IGF-I in muscular atrophy of aging.

S E Borst1, D T Lowenthal.   

Abstract

Loss of muscle mass and strength are well-known consequences of aging. The growth hormone/IGF-I pathway is both impaired with aging and essential for growth and maintenance of skeletal muscle. Despite this, growth hormone (GH) replacement has not been effective in increasing muscle mass and strength in the elderly. Possible explanations for this failure include 1. The presence of other age-related impairments in muscle that prevent the actions of GH and IGF-I and 2. Complications arising from a failure to deliver GH and IGF-I in the physiologically correct manner. This article summarizes the results of clinical trials of GH and IGF-I in the elderly and discusses the current status of strategies for safely and effectively stimulating the GH/IGF-I pathway in this population.

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Year:  1997        PMID： 9449034     DOI： 10.1007/BF02778065

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  9 in total

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Journal:  Endocr Rev       Date:  1993-02       Impact factor: 19.871

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Journal:  J Clin Endocrinol Metab       Date:  1995-06       Impact factor: 5.958

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Journal:  Ann Intern Med       Date:  1996-04-15       Impact factor: 25.391

6.  The insulin-like growth factor I generation test: resistance to growth hormone with aging and estrogen replacement therapy.

Authors:  S A Lieberman; A M Mitchell; R Marcus; R L Hintz; A R Hoffman
Journal:  Horm Metab Res       Date:  1994-05       Impact factor: 2.936

7.  Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly women.

Authors:  L J Ghiron; J L Thompson; L Holloway; R L Hintz; G E Butterfield; A R Hoffman; R Marcus
Journal:  J Bone Miner Res       Date:  1995-12       Impact factor: 6.741

8.  Effect of growth hormone and resistance exercise on muscle growth and strength in older men.

Authors:  K E Yarasheski; J J Zachwieja; J A Campbell; D M Bier
Journal:  Am J Physiol       Date:  1995-02

9.  Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.

Authors:  D R Taaffe; L Pruitt; J Reim; R L Hintz; G Butterfield; A R Hoffman; R Marcus
Journal:  J Clin Endocrinol Metab       Date:  1994-11       Impact factor: 5.958
  9 in total
  7 in total

Review 1.  The role of circulating IGF-I: lessons from human and animal models.

Authors:  Shoshana Yakar; Yiping Wu; Jennifer Setser; Clifford J Rosen
Journal:  Endocrine       Date:  2002-12       Impact factor: 3.633

2.  Measurement of cumulative physiological dysregulation in an older population.

Authors:  Christopher L Seplaki; Noreen Goldman; Maxine Weinstein; Yu-Hsuan Lin
Journal:  Demography       Date:  2006-02

3.  Corticotropin releasing factor 2 receptor agonists reduce the denervation-induced loss of rat skeletal muscle mass and force and increase non-atrophying skeletal muscle mass and force.

Authors:  R T Hinkle; E Donnelly; D B Cody; M B Bauer; R J Sheldon; R J Isfort
Journal:  J Muscle Res Cell Motil       Date:  2005-02-09       Impact factor: 2.698

4.  Does insulin-like growth factor 1 genotype influence muscle power response to strength training in older men and women?

Authors:  Suchi Sood; Erik D Hanson; Matthew J Delmonico; Matthew C Kostek; Brian D Hand; Stephen M Roth; Ben F Hurley
Journal:  Eur J Appl Physiol       Date:  2011-06-11       Impact factor: 3.078

5.  Quantitative estimation of muscle mass in older adults at risk of sarcopenia using ultrasound: a cross-sectional study.

Authors:  Xinyi Tang; Li Huang; Jirong Yue; Li Qiu
Journal:  Quant Imaging Med Surg       Date:  2022-04

Review 6.  Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults.

Authors:  Silvia Giovannini; Emanuele Marzetti; Stephen E Borst; Christiaan Leeuwenburgh
Journal:  Mech Ageing Dev       Date:  2008-08-13       Impact factor: 5.432

7.  Relationship between sleep and muscle strength among Chinese university students: a cross-sectional study.

Authors:  Y Chen; Y Cui; S Chen; Z Wu
Journal:  J Musculoskelet Neuronal Interact       Date:  2017-12-01       Impact factor: 2.041
  7 in total

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