Literature DB >> 9448747

Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse.

H Zaher1, T J Yang, H V Gelboin, P Fernandez-Salguero, F J Gonzalez.   

Abstract

Studies have suggested that phenobarbital (PB) induces members of the CYP1A subfamily by both transcriptional and post-transcriptional mechanisms. Using the Ahr -/- mice, we examined the induction of CYP1A1 and CYP1A2 by PB. CYP1A2 mRNA and protein were induced by PB in the null mice, suggesting that CYP1A2 is regulated by PB by a mechanism independent of the aryl hydrocarbon receptor (AHR). In contrast, the regulation of CYP1A1 is highly dependent on the AHR.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9448747     DOI： 10.1016/s0006-2952(97)00476-0

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  6 in total

Review 1.  Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.

Authors:  Antonia H Tolson; Hongbing Wang
Journal:  Adv Drug Deliv Rev       Date:  2010-08-17       Impact factor: 15.470

2.  Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.

Authors:  Y Shimizu; Y Nakatsuru; M Ichinose; Y Takahashi; H Kume; J Mimura; Y Fujii-Kuriyama; T Ishikawa
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

3.  Activation of the aryl hydrocarbon receptor by doxorubicin mediates cytoprotective effects in the heart.

Authors:  Maria Volkova; Monica Palmeri; Kerry S Russell; Raymond R Russell
Journal:  Cardiovasc Res       Date:  2011-01-13       Impact factor: 10.787

Review 4.  On the general mechanism of selective induction of cytochrome P450 enzymes by chemicals: some theoretical considerations.

Authors:  Bao Ting Zhu
Journal:  Expert Opin Drug Metab Toxicol       Date:  2010-04       Impact factor: 4.481

5.  Induction by Phenobarbital of Phase I and II Xenobiotic-Metabolizing Enzymes in Bovine Liver: An Overall Catalytic and Immunochemical Characterization.

Authors:  Michela Cantiello; Monica Carletti; Mery Giantin; Giulia Gardini; Francesca Capolongo; Paolo Cascio; Marianna Pauletto; Flavia Girolami; Mauro Dacasto; Carlo Nebbia
Journal:  Int J Mol Sci       Date:  2022-03-24       Impact factor: 5.923

6.  Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway.

Authors:  Akiko Hirano; Masashi Goto; Tsukasa Mitsui; Akiko Hashimoto-Hachiya; Gaku Tsuji; Masutaka Furue
Journal:  Int J Mol Sci       Date:  2017-09-11       Impact factor: 5.923
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.