Literature DB >> 9447969

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2.

K M Lonergan1, O Iliopoulos, M Ohh, T Kamura, R C Conaway, J W Conaway, W G Kaelin.   

Abstract

The von Hippel-Lindau tumor suppressor protein (pVHL) binds to elongins B and C and posttranscriptionally regulates the accumulation of hypoxia-inducible mRNAs under normoxic (21% O2) conditions. Here we report that pVHL binds, via elongin C, to the human homolog of the Caenorhabditis elegans Cul2 protein. Coimmunoprecipitation and chromatographic copurification data suggest that pVHL-Cul2 complexes exist in native cells. pVHL mutants that were unable to bind to complexes containing elongin C and Cul2 were likewise unable to inhibit the accumulation of hypoxia-inducible mRNAs. A model for the regulation of hypoxia-inducible mRNAs by pVHL is presented based on the apparent similarity of elongin C and Cul2 to Skp1 and Cdc53, respectively. These latter proteins form complexes that target specific proteins for ubiquitin-dependent proteolysis.

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Year:  1998        PMID： 9447969      PMCID： PMC108784          DOI： 10.1128/MCB.18.2.732

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  46 in total

1.  The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity.

Authors:  D Mukhopadhyay; B Knebelmann; H T Cohen; S Ananth; V P Sukhatme
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

Review 2.  The molecular basis of von Hippel-Lindau disease.

Authors:  O Iliopoulos; W G Kaelin
Journal:  Mol Med       Date:  1997-05       Impact factor: 6.354

Review 3.  Cell cycle: cull and destroy.

Authors:  P K Jackson
Journal:  Curr Biol       Date:  1996-10-01       Impact factor: 10.834

4.  Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues.

Authors:  C L Corless; A S Kibel; O Iliopoulos; W G Kaelin
Journal:  Hum Pathol       Date:  1997-04       Impact factor: 3.466

5.  Monoclonal antibodies specific for simian virus 40 tumor antigens.

Authors:  E Harlow; L V Crawford; D C Pim; N M Williamson
Journal:  J Virol       Date:  1981-09       Impact factor: 5.103

6.  Preferential modification of nuclear proteins by a novel ubiquitin-like molecule.

Authors:  T Kamitani; H P Nguyen; E T Yeh
Journal:  J Biol Chem       Date:  1997-05-30       Impact factor: 5.157

Review 7.  Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene.

Authors:  A P Levy; N S Levy; O Iliopoulos; C Jiang; W G Kaplin; M A Goldberg
Journal:  Kidney Int       Date:  1997-02       Impact factor: 10.612

8.  The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.

Authors:  A Pause; S Lee; R A Worrell; D Y Chen; W H Burgess; W M Linehan; R D Klausner
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

9.  Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan.

Authors:  B Zbar; T Kishida; F Chen; L Schmidt; E R Maher; F M Richards; P A Crossey; A R Webster; N A Affara; M A Ferguson-Smith; H Brauch; D Glavac; H P Neumann; S Tisherman; J J Mulvihill; D J Gross; T Shuin; J Whaley; B Seizinger; N Kley; S Olschwang; C Boisson; S Richard; C H Lips; M Lerman
Journal:  Hum Mutat       Date:  1996       Impact factor: 4.878

10.  Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations.

Authors:  T Kishida; T M Stackhouse; F Chen; M I Lerman; B Zbar
Journal:  Cancer Res       Date:  1995-10-15       Impact factor: 12.701
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  123 in total

1.  Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein.

Authors:  A Pause; B Peterson; G Schaffar; R Stearman; R D Klausner
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

Review 2.  Two distinct ubiquitin-proteolysis pathways in the fission yeast cell cycle.

Authors:  T Toda; I Ochotorena; K Kominami
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-09-29       Impact factor: 6.237

Review 3.  HIF hydroxylation and the mammalian oxygen-sensing pathway.

Authors:  Michal Safran; William G Kaelin
Journal:  J Clin Invest       Date:  2003-03       Impact factor: 14.808

Review 4.  HECT and RING finger families of E3 ubiquitin ligases at a glance.

Authors:  Meredith B Metzger; Ventzislava A Hristova; Allan M Weissman
Journal:  J Cell Sci       Date:  2012-02-01       Impact factor: 5.285

5.  The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

Authors:  J G Zhang; A Farley; S E Nicholson; T A Willson; L M Zugaro; R J Simpson; R L Moritz; D Cary; R Richardson; G Hausmann; B T Kile; B J Kile; S B Kent; W S Alexander; D Metcalf; D J Hilton; N A Nicola; M Baca
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

Review 6.  Breaking through a plateau in renal cell carcinoma therapeutics: development and incorporation of biomarkers.

Authors:  Sumanta Kumar Pal; Marcin Kortylewski; Hua Yu; Robert A Figlin
Journal:  Mol Cancer Ther       Date:  2010-11-15       Impact factor: 6.261

7.  von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.

Authors:  Michele M Hickey; Jennifer C Lam; Natalie A Bezman; W Kimryn Rathmell; M Celeste Simon
Journal:  J Clin Invest       Date:  2007-12       Impact factor: 14.808

8.  Von Hippel-Lindau gene deletion and expression of hypoxia-inducible factor and ubiquitin in optic nerve hemangioma.

Authors:  Chi-Chao Chan; Youn-Soo Lee; Zhengping Zhuang; Joseph Hackett; Emily Y Chew
Journal:  Trans Am Ophthalmol Soc       Date:  2004

9.  Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines.

Authors:  Yunkai Yu; Zuoxiang Xiao; Elana S Ehrlich; Xianghui Yu; Xiao-Fang Yu
Journal:  Genes Dev       Date:  2004-12-01       Impact factor: 11.361

10.  Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease.

Authors:  Gautam U Mehta; Sharon B Shively; Heng Duong; Maxine G B Tran; Travis J Moncrief; Jonathan H Smith; Jie Li; Nancy A Edwards; Russell R Lonser; Zhengping Zhuang; Marsha J Merrill; Mark Raffeld; Patrick H Maxwell; Edward H Oldfield; Alexander O Vortmeyer
Journal:  Neoplasia       Date:  2008-10       Impact factor: 5.715
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