AIMS: Intravascular lymphomatosis is an uncommon type of non-Hodgkin's lymphoma characterized by intravascular proliferation of neoplastic lymphoid cells. Although the tumour is basically a systemic disease, eventually involving multiple organs, primary presentation in the lung is rare. METHODS AND RESULTS: We describe the clinicopathological features of two patients with intravascular lymphomatosis presenting in the lung. One patient complained of fever, headache and chest pain; the other, of dyspnoea on exertion and headache. Both patients showed reticulonodular density on chest radiography and decreased diffusion capacity. Lung biopsy showed features characteristic of intravascular lymphomatosis. Malignant lymphoid cells were CD30 positive T-cells of anaplastic large cell type in one patient and B-cells of large cell type in the other. There was a poor response to chemotherapy and both patients died of the disease within 3 months of diagnosis. CONCLUSIONS: These cases and 10 previous reports illustrate the need to include intravascular lymphomatosis in the differential diagnosis of interstitial lung disease.
AIMS: Intravascular lymphomatosis is an uncommon type of non-Hodgkin's lymphoma characterized by intravascular proliferation of neoplastic lymphoid cells. Although the tumour is basically a systemic disease, eventually involving multiple organs, primary presentation in the lung is rare. METHODS AND RESULTS: We describe the clinicopathological features of two patients with intravascular lymphomatosis presenting in the lung. One patient complained of fever, headache and chest pain; the other, of dyspnoea on exertion and headache. Both patients showed reticulonodular density on chest radiography and decreased diffusion capacity. Lung biopsy showed features characteristic of intravascular lymphomatosis. Malignant lymphoid cells were CD30 positive T-cells of anaplastic large cell type in one patient and B-cells of large cell type in the other. There was a poor response to chemotherapy and both patients died of the disease within 3 months of diagnosis. CONCLUSIONS: These cases and 10 previous reports illustrate the need to include intravascular lymphomatosis in the differential diagnosis of interstitial lung disease.
Authors: T Wagner; D Brechemier; E Dugert; S Le Guellec; A Julian; A Hitzel; O Beyne-Rauzy Journal: Cancer Imaging Date: 2012-01-23 Impact factor: 3.909
Authors: Zhou Yu; Yifan Pang; Linda Wang; Daniel E Ezekwudo; Foluso Ogunleye; Susanna S Gaikazian; Mark Micale; James Huang; Ann Marie Blenc; Ishmael Jaiyesimi Journal: Case Rep Hematol Date: 2017-09-24
Authors: Vanessa Brunet; Sofia Marouan; Jean-Pierre Routy; Mohamed Amin Hashem; Vincent Bernier; Raynald Simard; Tony Petrella; Louis Lamarre; Gilles Théorêt; Christian Carrier; Hans Knecht; Isabelle Fleury; Michel Pavic Journal: Medicine (Baltimore) Date: 2017-02 Impact factor: 1.889