OBJECTIVE: We evaluated the therapeutic efficacy of radical gastrectomy for primary B-cell lymphoma of the stomach and attempted to identify patients who could be adequately treated with surgery alone. SUMMARY BACKGROUND DATA: Several recent gastric lymphoma reports have discussed the therapeutic benefits of various treatment strategies for stage IE and IIE lymphoma. However, few studies have been based on patients accurately staged by systematic lymphadenectomy with subsequent pathologic examination. METHODS: A retrospective study was performed to evaluate the survival and biologic behavior of lesions in 60 patients with gastric lymphoma who were treated by radical gastrectomy alone. Tumors were classified according to the histopathologic concept of mucosa-associated lymphoid tissue (MALT)-derived lymphoma. RESULTS: A low histopathologic grade was associated with a significantly lower incidence of nodal metastasis (p = 0.07) and less extensive infiltration of the gastric wall (p < 0.005) despite larger tumor size. A 5-year survival rate of >95% was attained with surgery alone for MALT lymphoma and for true stage IE lymphoma diagnosed by pathologic examination of up to N2 lymph nodes routinely performed after radical gastrectomy. CONCLUSIONS: Surgery alone is adequate treatment for stage IE or pure MALT lymphoma, provided that the staging is performed after radical gastrectomy.
OBJECTIVE: We evaluated the therapeutic efficacy of radical gastrectomy for primary B-cell lymphoma of the stomach and attempted to identify patients who could be adequately treated with surgery alone. SUMMARY BACKGROUND DATA: Several recent gastric lymphoma reports have discussed the therapeutic benefits of various treatment strategies for stage IE and IIE lymphoma. However, few studies have been based on patients accurately staged by systematic lymphadenectomy with subsequent pathologic examination. METHODS: A retrospective study was performed to evaluate the survival and biologic behavior of lesions in 60 patients with gastric lymphoma who were treated by radical gastrectomy alone. Tumors were classified according to the histopathologic concept of mucosa-associated lymphoid tissue (MALT)-derived lymphoma. RESULTS: A low histopathologic grade was associated with a significantly lower incidence of nodal metastasis (p = 0.07) and less extensive infiltration of the gastric wall (p < 0.005) despite larger tumor size. A 5-year survival rate of >95% was attained with surgery alone for MALT lymphoma and for true stage IE lymphoma diagnosed by pathologic examination of up to N2 lymph nodes routinely performed after radical gastrectomy. CONCLUSIONS: Surgery alone is adequate treatment for stage IE or pure MALT lymphoma, provided that the staging is performed after radical gastrectomy.
Authors: J Pedersen-Bjergaard; J Ersbøll; V L Hansen; B L Sørensen; K Christoffersen; K Hou-Jensen; N I Nissen; J B Knudsen; M M Hansen Journal: N Engl J Med Date: 1988-04-21 Impact factor: 91.245
Authors: F A Shepherd; W K Evans; G Kutas; J C Yau; P Dang; J G Scott; H A Farquharson; W H Francombe; D Bailey; M A Baker Journal: J Clin Oncol Date: 1988-02 Impact factor: 44.544
Authors: J Pedersen-Bjergaard; J Ersbøll; H M Sørensen; N Keiding; S O Larsen; P Philip; M S Larsen; H Schultz; N I Nissen Journal: Ann Intern Med Date: 1985-08 Impact factor: 25.391
Authors: Andrea Morgner; Renate Schmelz; Christian Thiede; Manfred Stolte; Stephan Miehlke Journal: World J Gastroenterol Date: 2007-07-14 Impact factor: 5.742
Authors: Mircea Nicolae Brătucu; Virgiliu-Mihail Prunoiu; Victor Strâmbu; Eugen Brătucu; Maria-Manuela Răvaş; Laurenţiu Simion; Radu Petre Journal: Medicina (Kaunas) Date: 2021-12-09 Impact factor: 2.430